3-Amino-4-methylpyridine Chemical Properties

Melting point:

102-107 °C

Boiling point:

254°C

Density 

1.0275 (estimate)

refractive index 

1.5560 (estimate)

Flash point:

254°C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform, Ethyl Acetate, Methanol

form 

powder to crystal

pka

6.83±0.18(Predicted)

color 

White to Brown

Sensitive 

Hygroscopic

BRN 

107792

InChI

InChI=1S/C6H8N2/c1-5-2-3-8-4-6(5)7/h2-4H,7H2,1H3

InChIKey

IBKMZYWDWWIWEL-UHFFFAOYSA-N

SMILES

C1=NC=CC(C)=C1N

CAS DataBase Reference

3430-27-1(CAS DataBase Reference)

NIST Chemistry Reference

3-Pyridinamine, 4-methyl-(3430-27-1)

Safety Information

Hazard Codes 

T,Xn

Risk Statements 

23/24/25-36/37/38-41-37/38-22-20/21/22

Safety Statements 

26-36/37/39-45-36

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Toxic

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:ALFA

3-Amino-4-methylpyridine Usage And Synthesis

Application

3-Amino-4-methylpyridine is an important pharmaceutical and chemical intermediate, widely used in the synthesis and research and development of pharmaceuticals, pesticides, and veterinary drugs, and has high application and market value.

Chemical Properties

White to brown crystal or powder

Definition

3-amido-4-methylpyridine could synthesize 2-chlorin-3-amido-4-methyl pyridine through chlorination, the key intermediate of synthesizing anti-AIDS pharmaceutical nevirapine.

Synthesis

3-Amino-4-methylpyridine could be synthesized through the reaction of 4-methylpyridine and N₂O₅.

References

[1] Patent: EP1428824, 2004, A1. Location in patent: Page 42
[2] Tetrahedron Letters, 2010, vol. 51, # 5, p. 786 - 789
[3] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 1, p. 99 - 104
[4] Bulletin de la Societe Chimique de France, 1992, # 1, p. 79 - 84
[5] Chemische Berichte, 1927, vol. 60, p. 2108

3-Amino-4-methylpyridine(3430-27-1)Related Product Information

• 3-Aminopyridine
• Bensulfuron methyl
• 6-Aminocaproic acid
• ALTRENOGEST
• METSULFURON METHYL
• 3-Aminophenol
• 2-Aminopyridine
• Glycine
• Methyl acrylate
• 4-Methylpyridine
• Methyl acetate
• Methylparaben
• Azamethiphos
• 2,6-Lutidine
• 4-Pyridinemethaneamine
• 4-Dimethylaminopyridine
• Thiophanate-methyl
• Tris(hydroxymethyl)aminomethane