4-Chloro-2-methylthiopyrimidine Chemical Properties

Melting point:

−2 °C(lit.)

Boiling point:

139-140 °C36 mm Hg(lit.)

Density 

1.381 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.6(lit.)

Flash point:

>230 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

liquid

pka

-0.56±0.20(Predicted)

color 

Colorless to Red to Green

Water Solubility 

Not miscible or difficult to mix in water.

Sensitive 

Hygroscopic

BRN 

118042

InChIKey

DFOHHQRGDOQMKG-UHFFFAOYSA-N

CAS DataBase Reference

49844-90-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 1760 8/PG 2

WGK Germany 

3

F 

10-13-23

Hazard Note 

Corrosive/Hygroscopic

HazardClass 

8

PackingGroup 

III

HS Code 

29335990

MSDS

• Language:English Provider:4-Chloro-2-methylthiopyrimidine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Chloro-2-methylthiopyrimidine Usage And Synthesis

Chemical Properties

Clear yellow to brown liquid

Uses

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Uses

4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. It was used as building block in medicinal chemistry synthesis.

4-Chloro-2-methylthiopyrimidine(49844-90-8)Related Product Information

• Phenyl chlorothionocarbonate
• ISOMETHIOZIN
• Pyrimidine
• Sulfamerazine
• tert-Butyldimethylsilyl chloride
• Meclofenoxate hydrochloride
• 2-(Dimethylamino)ethyl (4-chlorphenoxy)acetate
• 4-Chloropyrimidine
• 2-Chloro-5-chloromethylpyridine
• Chloromethyltrimethylsilane
• Chlorantraniliprole
• MCPA SODIUM
• Pirimiphos-methyl
• Thioridazine
• Difluorochloromethane
• 4,6-DICHLORO-2-METHYLTHIO-5-PHENYLPYRIMIDINE
• 5-Bromo-4-chloro-2-(methylthio)pyrimidine ,97%,5-Bromo-4-chloro-2-(methylthio)pyrimidine
• Chloromethyl methyl ether