1-hydroxycyclobutane-1-carboxylic acid Chemical Properties

Melting point:

68 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))

Boiling point:

120 °C

Density 

1.476±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

4.05±0.20(Predicted)

Appearance

Light brown to brown Solid

InChI

InChI=1S/C5H8O3/c6-4(7)5(8)2-1-3-5/h8H,1-3H2,(H,6,7)

InChIKey

XCBNHDSVRQZWLH-UHFFFAOYSA-N

SMILES

C1(O)(C(O)=O)CCC1

1-hydroxycyclobutane-1-carboxylic acid Usage And Synthesis

Physical Form

Solid

Uses

1-Hydroxycyclobutanecarboxylic Acid is used in preparation of piperidines or piperidones substituted with urea and heteroaryl as FPR2 modulators.

structure and hydrogen bonding

1-Hydroxy-cyclobutanecarboxylic acid is a potential chelating molecule bearing the conformational rigid cyclobutane group.

References

[1] Richard Betz, Peter Klüfers. “1-Hydroxycyclobutane-1-carboxylic acid.” Acta crystallographica. Section E, Structure reports online 63 10 (2007): o4032.