Trimethyl orthobenzoate Chemical Properties

Boiling point:

87-88 °C/7 mmHg (lit.)

Density 

1.061 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.489(lit.)

Flash point:

180 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in organic solvents.

form 

Liquid

color 

Clear colorless

Sensitive 

Moisture Sensitive

BRN 

777623

Stability:

Hygroscopic

InChIKey

IECKAVQTURBPON-UHFFFAOYSA-N

CAS DataBase Reference

707-07-3(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, (trimethoxymethyl)-(707-07-3)

EPA Substance Registry System

Benzene, (trimethoxymethyl)- (707-07-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

WGK Germany 

3

TSCA 

Yes

HS Code 

29163100

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Trimethyl orthobenzoate Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1661, 1950 DOI: 10.1021/ja01160a067

General Description

Trimethyl orthobenzoate reacts with P-dimethylaminophosphonic acid bis(1-methylhydrazide) to yield 1,2,5,6-tetrahydro-1,5-dimethyl-6-(N,N-dimethylamino)-6-phenyl-1,2,4,5,6-tetrazaphosphorine-6-oxide.

Trimethyl orthobenzoate(707-07-3)Related Product Information

• Trimethyl orthoacetate
• Methyl 2-bromobenzoate
• Methyl 4-cyanobenzoate
• Methyl 4-(bromomethyl)benzoate
• Trimethoxymethane
• Methyl benzoate
• Methylparaben
• Methyl 4-methylbenzoate
• Trimethyl borate
• Triethyl orthobenzoate
• Trimethyl orthopropionate
• Triethyl orthopropionate
• Trimethyl orthobutyrate
• TRIS(2-CHLOROETHYL)- ORTHOFORMATE
• Triphenylmethanol
• TRIPHENYL PHOSPHOROTHIONATE
• ORTHODICHLOROACETIC ACID TRIETHYL ESTER
• Tripropyl orthoformate