DIMINAZENE ACETURATE
DIMINAZENE ACETURATE Basic information
- Product Name:
- DIMINAZENE ACETURATE
- Synonyms:
-
- CL218
- Glycine, N-acetyl-, compd. with 4,4'-(1-triazene-1,3-diyl)bis[benzenecarboximidamide] (2:1)
- 4,4’-(diamino)dibenzamidediaceturate
- 4,4’-(Diazoamino)dibenzamidinediaceturate
- ganasag
- ganaseg
- glycine,n-acetyl-,compd.with4,4’-(1-triazene-1,3-diyl)bis(benzenecarboxim
- glycine,n-acetyl-,compd.with4,4’-(1-triazene-1,3-diyl)bis[benzenecarboximid
- CAS:
- 908-54-3
- MF:
- C22H29N9O6
- MW:
- 515.52
- EINECS:
- 212-999-2
- Product Categories:
-
- BERENIL
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 908-54-3.mol
DIMINAZENE ACETURATE Chemical Properties
- Melting point:
- 202 °C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- powder
- color
- Orange to Dark Orange
- Water Solubility
- Soluble to 100 mM in water
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 908-54-3(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
DIMINAZENE ACETURATE Usage And Synthesis
Description
Diminazene is a diamidine that is cytotoxic to protozoa, including Trypanosoma, Babesia, and Cytauxzoon. Diamidines, including diminazene, affect a variety of enzymes and modulate interactions between nucleic acids and proteins. Diminazene inhibits diamine oxidase with a Ki value of 13 nM. In Trypanosoma, transport proteins are important in the effectiveness of diminazene. In rats and in vitro, diminazene enhances the enzymatic activity of angiotensin-converting enzyme 2.
Chemical Properties
solid
Uses
antiprotozoal as aceturate
Uses
An anti-protozoal and anti-trypanosomal compound
Uses
Diminazene aceturate is an anti-protozoal drug. Diminazene Diaceturate is used as an anti-trypanosomal agent.
Definition
ChEBI: An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine.
Veterinary Drugs and Treatments
Diminazene is used to treat trypanosomiasis in dogs and livestock (sheep, goats, cattle), Babesia infections in dogs and horses, and cytauxzoonosis in cats. The drug is not commercially available in the USA, but is available and used in many countries.
storage
Store at RT
References
[1] J MOSQUEDA. Current advances in detection and treatment of babesiosis.[J]. Current medicinal chemistry, 2012, 19 10: 1504-1518. DOI: 10.2174/092986712799828355
[2] GEORGE LAYLSON DA SILVA OLIVEIRA Rivelilson M de F. Diminazene aceturate—An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics[J]. Pharmacological research, 2015, 102: Pages 138-157. DOI: 10.1016/j.phrs.2015.10.005
[3] TIEN L. HUANG Jean J V E Annie Mayence. Some non-conventional biomolecular targets for diamidines. A short survey[J]. Bioorganic & Medicinal Chemistry, 2014, 22 7: Pages 1983-1992. DOI: 10.1016/j.bmc.2014.02.049
[4] JANE C MUNDAY H P de K Luca Settimo. Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei.[J]. Frontiers in Pharmacology, 2015, 6: 32. DOI: 10.3389/fphar.2015.00032
[5] VINAYAK SHENOY. Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.[J]. American journal of respiratory and critical care medicine, 2013, 187 6: 648-657. DOI: 10.1164/rccm.201205-0880oc
DIMINAZENE ACETURATE Preparation Products And Raw materials
Raw materials
DIMINAZENE ACETURATESupplier
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- marketing_china@spectrumchemical.com
- Tel
- +86 21 61551611
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com