Fmoc-L-glutamic acid 5-tert-butyl ester Chemical Properties

Melting point:

83-90 °C

alpha 

-4.5 º (c=1, 80% acetic acid)

Boiling point:

633.5±55.0 °C(Predicted)

Density 

1.232±0.06 g/cm3(Predicted)

refractive index 

-4 ° (C=1, 80% AcOH)

storage temp. 

Store below +30°C.

solubility 

soluble in Methanol

form 

powder to crystal

pka

3.70±0.10(Predicted)

color 

White to Almost white

optical activity

[α]20/D 5.0±2.0°, c = 1% in acetic acid: water (4:1)

BRN 

3636375

InChIKey

OTKXCALUHMPIGM-FQEVSTJZSA-N

SMILES

C(O)(=O)[C@H](CCC(OC(C)(C)C)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

CAS DataBase Reference

71989-18-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-27-36/37/39-24/25

WGK Germany 

3

HS Code 

2924 29 70

MSDS

• Language:English Provider:Fmoc-Glu(OtBu)-OH
• Language:English Provider:SigmaAldrich

Fmoc-L-glutamic acid 5-tert-butyl ester Usage And Synthesis

Description

Fmoc-L-glutamic acid 5-tert-butyl ester is a Fmoc derivative with an N-substituted tert-butyl ester molecule. It is white or gray-white solid crystals at room temperature and pressure, poor solubility in water and insoluble in petroleum ether, but soluble in ethyl acetate, acetic acid and N,N-dimethylformamide.

Chemical Properties

White powder

Uses

Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a:

• Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.
• Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.

It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters .

General Description

The product number for this product was previously 04-12-1020.

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Fmoc-L-glutamic acid 5-tert-butyl ester(71989-18-9)Related Product Information

• butyl rubber
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• CARBONYL SULFIDE
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• Butyl acetate
• Methyl 4-tert-butylbenzoate
• 9-Fluorenylmethyl chloroformate
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• 4-tert-Butylcatechol
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