ETHYL INDOLE-5-CARBOXYLATE Chemical Properties

Melting point:

96.5-97.5 °C

Boiling point:

342.4±15.0 °C(Predicted)

Density 

1.210±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

16.09±0.30(Predicted)

Appearance

White to off-white Solid

CAS DataBase Reference

32996-16-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2933998090

ETHYL INDOLE-5-CARBOXYLATE Usage And Synthesis

Uses

Ethyl Indole-5-carboxylate is used as a reagent in the synthesis of pyrazole-based cathepsin S inhibitors.

Synthesis

Graphene oxide (GO, 50 wt% by mass of indole-5-carboxylic acid) was added as indole-5-carboxylic acid (0.2 mmol) and ethanol (0.6 mmol) in ethanol or dichloroethane (DCE, 1 mL), and the mixture was transferred to a test tube equipped with a magnetic stirrer. The reaction was stirred at 100 °C for 24 h. After completion of the reaction, the GO was removed by filtration, the solvent was removed by distillation under reduced pressure, and the residue was purified by column chromatography to give ethyl indole-5-carboxylate in pure form.

References

[1] Organic Letters, 2017, vol. 19, # 6, p. 1314 - 1317
[2] Journal of the American Chemical Society, 2017, vol. 139, # 23, p. 7745 - 7748
[3] Synlett, 2017, vol. 28, # 8, p. 981 - 985
[4] Patent: WO2009/47240, 2009, A1. Location in patent: Page/Page column 42

ETHYL INDOLE-5-CARBOXYLATE(32996-16-0)Related Product Information

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• ETHYL INDOLE-3-CARBOXYLATE
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• Indole-5-carboxaldehyde
• Indole-3-carboxaldehyde
• Indole-4-carboxaldehyde
• Indole-4-carboxylic acid
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• 1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE
• Indole-3-glyoxylic acid