CHEMBRDG-BB 5280909 Chemical Properties

Melting point:

178-179 °C(Solv: 1,4-dioxane (123-91-1))

Boiling point:

544.0±50.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide

pka

14.47±0.10(Predicted)

form 

powder

color 

white to beige

Safety Information

RIDADR 

UN 2811 6.1 / PGIII

CHEMBRDG-BB 5280909 Usage And Synthesis

Description

ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC₅₀ = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC₅₀ = 10 μM) in isolated human platelets.

Uses

ML-354 is a selective protease activated receptor 4 ( PAR-4) antagonist used for its antithrombotic effects.

Biochem/physiol Actions

ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist.

IC 50

140 nm

storage

Store at -20°C

References

[1]. wen, w., young, s., duvernay, m., schulte, m., nance, k., & melancon, b. et al. substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and sar of ml354. bioorganic & medicinal chemistry letters. 2014; 24(19): 4708-4713.

CHEMBRDG-BB 5280909(89159-60-4)Related Product Information

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• CHEMBRDG-BB 5280909