2-Hydroxy-3-trifluoromethylpyridine Chemical Properties

Melting point:

150-153°C

Boiling point:

223.7±40.0 °C(Predicted)

Density 

1.398±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

9.67±0.10(Predicted)

color 

White to Almost white

InChI

InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)

InChIKey

JHDCDEHVUADNKQ-UHFFFAOYSA-N

SMILES

C1(=O)NC=CC=C1C(F)(F)F

LogP

0.71 at 25℃

CAS DataBase Reference

22245-83-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn,T

Risk Statements 

36/37/38-65-20/21/22-20/21-36-25

Safety Statements 

26-36/37/39-36-45

RIDADR 

UN2811

HazardClass 

IRRITANT

HS Code 

29333990

2-Hydroxy-3-trifluoromethylpyridine Usage And Synthesis

Description

2-hydroxy-3-(trifluoromethyl)pyridine (or 3-(Trifluoromethyl)-2-pyridone) is a trifluoromethyl substituted 2-hydroxypyridine. It is used as a synthesis intermediate for ligands and bioactive ingredients in the application of drug discovery and catalytic reactions. In catalytic reactions, the amide group of 2-pyridone binds to transition metals, forming stable 5-/6-membered ring intermediates. Hence, 2-hydroxy-3-(trifluoromethyl)pyridine is widely used as a ligand in catalytic reactions such as directed C-H activation on meta-position. In addition, the trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.

Chemical Properties

White powder

Uses

2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .

2-Hydroxy-3-trifluoromethylpyridine(22245-83-6)Related Product Information

• 2-Chloro-3-hydroxypyridine
• Azamethiphos
• CHLOROPHOSPHONAZO III
• 2-Chloro-3-(trifluoromethyl)pyridine
• 3-Hydroxypyridine
• 2,4,6-Collidine
• 2-(Trifluoromethyl)benzoic acid
• 3-(Trifluoromethyl)benzaldehyde
• 2-Hydroxypyridine
• 4-Methylpyridine
• 4-(Trifluoromethyl)pyridine
• 2-(Trifluoromethyl)pyridine
• 3-Trifluoromethylpyridine
• 2-Hydroxy-6-methyl-5-nitropyridine
• 2-Hydroxy-4-methoxybenzaldehyde
• 2-Hydroxy-4-methyl-5-nitropyridine
• 2-Hydroxy-4-methyl-3-nitropyridine
• 3-BROMO-6-HYDROXY-2-METHYLPYRIDINE