H-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2 Chemical Properties

Density 

1.44±0.1 g/cm3(Predicted)

storage temp. 

-15°C

form 

Solid

pka

9.96±0.15(Predicted)

color 

White to off-white

Sequence

Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2

H-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2 Usage And Synthesis

Uses

PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research[1][2][3].

Biological Activity

Endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP) but with a greater potency for stimulation of adenylyl cyclase.

References

[1] Moody TW, et, al. PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner. Peptides. 2019 Oct;120:170017. DOI:10.1016/j.peptides.2018.09.005
[2] Kojro E, et, al. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. FASEB J. 2006 Mar;20(3):512-4. DOI:10.1096/fj.05-4812fje
[3] Braas KM, et, al. Pituitary adenylate cyclase-activating polypeptides, PACAP-38 and PACAP-27, regulation of sympathetic neuron catecholamine, and neuropeptide Y expression through activation of type I PACAP/VIP receptor isoforms. Ann N Y Acad Sci. 1996 De DOI:10.1111/j.1749-6632.1996.tb17484.x

H-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2(138764-85-9)Related Product Information

• H-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2
• H-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2
• PACAP 1-27
• PACAP38
• DVAHEILNEAYRKVLDQLSARKYLQSMVA
• H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-LYS(BIOTIN)-NH2
• PACAP (1-38), frog
• PACAP 6-38
• H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2
• L(+)-Arginine
• Argon
• H-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2
• ([125I]-TYR)-PACAP-38 (31-38) (HUMAN, CHICKEN, MOUSE, OVINE, PORCINE, RAT)
• H-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2