4ALPHA-PHORBOL 12,13-DIDECANOATE Chemical Properties

storage temp. 

-20°C

solubility 

DMSO: soluble

form 

solid

color 

white

BRN 

2514324

Safety Information

Hazard Codes 

T+

Risk Statements 

26/27/28-40-43

Safety Statements 

36/37/39-45

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

F 

8-10

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

4ALPHA-PHORBOL 12,13-DIDECANOATE Usage And Synthesis

Uses

4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:

• to study its effects on Madin-Darby canine kidney (MDCK) cells
• to study its effects on Ca²⁺ influx in mice fallopian tubal cells
• to study its effects on hind paw swelling in mice

Definition

ChEBI: 4alpha-phorbol 12,13-didecanoate is a phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding decanoate esters. A Trpv4-specific ligand. It has a role as a TRPV4 agonist. It is a phorbol ester, a decanoate ester, a tertiary alpha-hydroxy ketone, a diester and a primary allylic alcohol.

Biochem/physiol Actions

4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells.

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