Basic information Safety Supplier Related

4ALPHA-PHORBOL 12,13-DIDECANOATE

Basic information Safety Supplier Related

4ALPHA-PHORBOL 12,13-DIDECANOATE Basic information

Product Name:
4ALPHA-PHORBOL 12,13-DIDECANOATE
Synonyms:
  • 4ALPHA-PDD
  • 4ALPHA-PHORBOL 12-13-DICAPRINATE
  • 4ALPHA-PHORBOL 12,13-DIDECANOATE
  • 4a-Phorbol-12,13-didecanoate
  • 4A-PHORBOL 12,13-DIDECANOATE WEAK PROTEI N KINASE C
  • 4α-phorbol 12-13-dicaprinate
  • 4A-PHORBOL 12,13-DIDECANOATE, 99+%
  • phorbol (4alpha-) 12,13-didecanoate
CAS:
27536-56-7
MF:
C40H64O8
MW:
672.93
Product Categories:
  • metabolite
Mol File:
27536-56-7.mol
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4ALPHA-PHORBOL 12,13-DIDECANOATE Chemical Properties

storage temp. 
-20°C
solubility 
DMSO: soluble
form 
solid
color 
white
BRN 
2514324
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28-40-43
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
8-10
HazardClass 
6.1(b)
PackingGroup 
III

MSDS

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4ALPHA-PHORBOL 12,13-DIDECANOATE Usage And Synthesis

Uses

4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:

  • to study its effects on Madin-Darby canine kidney (MDCK) cells
  • to study its effects on Ca2+ influx in mice fallopian tubal cells
  • to study its effects on hind paw swelling in mice

Definition

ChEBI: 4alpha-phorbol 12,13-didecanoate is a phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding decanoate esters. A Trpv4-specific ligand. It has a role as a TRPV4 agonist. It is a phorbol ester, a decanoate ester, a tertiary alpha-hydroxy ketone, a diester and a primary allylic alcohol.

Biochem/physiol Actions

4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells.

4ALPHA-PHORBOL 12,13-DIDECANOATESupplier

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