MPEP Chemical Properties

Melting point:

45-45.5 °C

Boiling point:

124.5-126.5 °C(Press: 0.5 Torr)

Density 

1.10±0.1 g/cm3(Predicted)

storage temp. 

Desiccate at +4°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Off-white powder.

pka

2.97±0.12(Predicted)

color 

White to Off-White

Stability:

Light Sensitive

MPEP Usage And Synthesis

Uses

A potent, subtype selective mGluR5 antagonist

Uses

2-Methyl-6-(2-phenylethynyl)pyridine induces pathophysiological mGluR5 signaling in Alzheimer''s disease model mice in sex-selective manner.

Uses

MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).

Definition

ChEBI: 2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as a metabotropic glutamate receptor antagonist and an anxiolytic drug. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.

Biological Activity

Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™ .

References

[1] gasparini f, lingenhöhl k, stoehr n, et al. 2-methyl-6-(phenylethynyl)-pyridine (mpep), a potent, selective and systemically active mglu5 receptor antagonist. neuropharmacology, 1999, 38(10): 1493-1503.
[2] tatarczyńska e, kłodzińska a, chojnacka-wójcik e, et al. potential anxiolytic-and antidepressant-like effects of mpep, a potent, selective and systemically active mglu5 receptor antagonist. british journal of pharmacology, 2001, 132(7): 1423-1430.

MPEP(96206-92-7)Related Product Information

• 3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE
• 2-ETHYNYL-6-METHYL-PYRIDINE
• 2-ETHYNYLPYRIDINE
• MPEP