3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE Chemical Properties

Melting point:

187-190 °C(lit.)

Boiling point:

50 °C(Press: 40 Torr)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

2000g/l

form 

Solid

color 

White to Off-White

PH

5-6 (500g/l, H2O, 20℃)

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

3670046

InChI

InChI=1S/C5H12ClN.ClH/c1-7(2)5-3-4-6;/h3-5H2,1-2H3;1H

InChIKey

LJQNMDZRCXJETK-UHFFFAOYSA-N

SMILES

C(CCCl)N(C)C.Cl

CAS DataBase Reference

5407-04-5(CAS DataBase Reference)

EPA Substance Registry System

3-Chloro-N,N-dimethyl-1-propanamine hydrochloride (5407-04-5)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-52/53

Safety Statements 

26-61-37/39-36

WGK Germany 

3

RTECS 

TY1225000

F 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29211990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White to yellowish crystalline powder

Uses

Dimethylaminopropyl chloride, hydrochloride is used mainly as a pharmaceutical intermediate for the synthesis of many types of drugs, as an agricultural chemical intermediate, as a photographic chemical intermediate, and as a biochemical reagent for enzyme and other studies. The compound shows mutagenic activity.

Uses

3-(Dimethylamino)propyl chloride hydrochloride (DMPC) is used as intermediate for the syntheses of pharmaceuticals (e.g. amitriptyline, bencyclane, benzydamine, cyclobenzaprine and imipramine). Product Data Sheet

Synthesis

Dithionyl chloride (21 g, 1.2 eq.) was added slowly and dropwise to a stirred solution of 3-dimethylamino-1-propanol (15 g, 1.0 eq.) dissolved in 150 mL of chloroform at 0 °C. Subsequently, the reaction mixture was heated to reflux and maintained for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was washed with a mixture of dichloromethane and petroleum ether (1:10, 50 mL, v/v) to give N,N-dimethylaminopropyl chloride hydrochloride (22 g, 98% yield).

References

[1] Patent: WO2013/97773, 2013, A1. Location in patent: Paragraph 0248
[2] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 5, p. 671 - 679

3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE(5407-04-5)Related Product Information

• Calcium chloride
• 4-Dimethylaminobenzoic acid
• 4-Dimethylaminopyridine
• Ammonium chloride
• Choline chloride
• Polyvinyl chloride
• Sodium chloride
• Aminoacetonitrile hydrochloride
• Ferric chloride
• Topotecan hydrochloride
• D-Glucosamine hydrochloride
• 4-Dimethylaminobenzaldehyde
• Sulfuryl chloride
• Aminoguanidine hydrochloride
• Potassium chloride
• 3-Dimethylamino-2-methylpropyl chloride hydrochloride
• Methylene Chloride
• Difluorochloromethane