3-Methylamino-1,2-propanediol
3-Methylamino-1,2-propanediol Basic information
- Product Name:
- 3-Methylamino-1,2-propanediol
- Synonyms:
-
- N-METHYL-3-AMINO-1,2-PROPANEDIOL
- 3-(AMINOMETHYL)-1,2-PROPANEDIOL
- 3-METHYLAMINO-PROPANE-1,2-DIOL
- 3-METHYLAMINO-1,2-PROPANEDIOL
- 2,3-Dihydroxy-N-methylpropylamine
- 3-Methylamino-1,2-Propandiol
- N-Methyl-2,3-dihydroxypropylamine
- 1,2-Propanediol, 3-(methylamino)-
- CAS:
- 40137-22-2
- MF:
- C4H11NO2
- MW:
- 105.14
- EINECS:
- 254-809-0
- Product Categories:
-
- Amino Alcohols
- Organic Building Blocks
- API
- Oxygen Compounds
- bc0001
- 40137-22-2
- Mol File:
- 40137-22-2.mol
3-Methylamino-1,2-propanediol Chemical Properties
- Melting point:
- 69°C (estimate)
- Boiling point:
- 247 °C
- Density
- 1.095 g/mL at 20 °C(lit.)
- refractive index
- n20/D 1.476
- Flash point:
- 152 °C
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 14.09±0.20(Predicted)
- form
- clear liquid
- color
- Colorless to Almost colorless
- Specific Gravity
- 1.0921
- PH
- 11.5 (100g/l, H2O, 20℃)
- Water Solubility
- miscible
- BRN
- 1733341
- CAS DataBase Reference
- 40137-22-2(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- RIDADR
- 2735
- WGK Germany
- 3
- F
- 3-10-34
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29221980
- Toxicity
- LD50 orally in Rabbit: > 2000 mg/kg
MSDS
- Language:English Provider:3-Methylamino-1,2-propanediol
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
3-Methylamino-1,2-propanediol Usage And Synthesis
Description
3-Methylamino-1,2-propanediol (MAPD) is a clear liquid with the chemical formula C4H11NO2. It can be synthesized from allylamine and alkanolamine via a thermal process. It reacts with chloride to form methyl chloroacetate, which can then be converted into 3-methylamino-1,2-propanediol by reaction with methanol. The production process for this substance has been shown to generate low levels of hazardous substances such as polycyclic aromatic hydrocarbons (PAHs) and dioxins.
Chemical Properties
clear colorless to pale yellow viscous liquid
Uses
3-Methylamino-1,2-propanediol is a reactive compound that is used in the synthesis of organic acids. It is also used as an intermediate in the manufacture of polyethylene glycols and particle coatings.
Definition
ChEBI: 3-methylamino-1,2-propanediol is a secondary amine.
Preparation
3-Methylamino-1,2-propanediol (MAPD) is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with
monomethyl amine in alkaline environment by adding sodium hydroxide.
Afterwards, the product undergoes a series of purification steps.
N-Methyl-1-amino-2,3-propandiol (45A) Methylamine (172ml of a 40% solution in water, 2 mol) was cooled to 0 °C and 2,3-epoxy-1-propanol (25g, 0.34mol) was added at a rate to maintain the temperature at or below 10 °C. The mixture was stirred for 3 hours at 0 °C. Excess methylamine and water was evaporated in vacuo and the product was purified by distillation at 103-105 °C, at 0.5 mm Hg, to give the compound 3-Methylamino-1,2-propanediol.
Hazard
3-Methylamino-1,2-propanediol is danger.
H314 (32.76%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H315 (67.24%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (65.52%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
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3-Methylamino-1,2-propanediol(40137-22-2)Related Product Information
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