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3-Methylamino-1,2-propanediol

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3-Methylamino-1,2-propanediol Basic information

Product Name:
3-Methylamino-1,2-propanediol
Synonyms:
  • N-METHYL-3-AMINO-1,2-PROPANEDIOL
  • 3-(AMINOMETHYL)-1,2-PROPANEDIOL
  • 3-METHYLAMINO-PROPANE-1,2-DIOL
  • 3-METHYLAMINO-1,2-PROPANEDIOL
  • 2,3-Dihydroxy-N-methylpropylamine
  • 3-Methylamino-1,2-Propandiol
  • N-Methyl-2,3-dihydroxypropylamine
  • 1,2-Propanediol, 3-(methylamino)-
CAS:
40137-22-2
MF:
C4H11NO2
MW:
105.14
EINECS:
254-809-0
Product Categories:
  • Amino Alcohols
  • Organic Building Blocks
  • API
  • Oxygen Compounds
  • bc0001
  • 40137-22-2
Mol File:
40137-22-2.mol
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3-Methylamino-1,2-propanediol Chemical Properties

Melting point:
69°C (estimate)
Boiling point:
247 °C
Density 
1.095 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.476
Flash point:
152 °C
storage temp. 
Inert atmosphere,Room Temperature
pka
14.09±0.20(Predicted)
form 
clear liquid
color 
Colorless to Almost colorless
Specific Gravity
1.0921
PH
11.5 (100g/l, H2O, 20℃)
Water Solubility 
miscible
BRN 
1733341
CAS DataBase Reference
40137-22-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
RIDADR 
2735
WGK Germany 
3
3-10-34
HazardClass 
8
PackingGroup 
II
HS Code 
29221980
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg

MSDS

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3-Methylamino-1,2-propanediol Usage And Synthesis

Description

3-Methylamino-1,2-propanediol (MAPD) is a clear liquid with the chemical formula C4H11NO2. It can be synthesized from allylamine and alkanolamine via a thermal process. It reacts with chloride to form methyl chloroacetate, which can then be converted into 3-methylamino-1,2-propanediol by reaction with methanol. The production process for this substance has been shown to generate low levels of hazardous substances such as polycyclic aromatic hydrocarbons (PAHs) and dioxins.

Chemical Properties

clear colorless to pale yellow viscous liquid

Uses

3-Methylamino-1,2-propanediol is a reactive compound that is used in the synthesis of organic acids. It is also used as an intermediate in the manufacture of polyethylene glycols and particle coatings.

Definition

ChEBI: 3-methylamino-1,2-propanediol is a secondary amine.

Preparation

3-Methylamino-1,2-propanediol (MAPD) is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with monomethyl amine in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps.  

N-Methyl-1-amino-2,3-propandiol (45A) Methylamine (172ml of a 40% solution in water, 2 mol) was cooled to 0 °C and 2,3-epoxy-1-propanol (25g, 0.34mol) was added at a rate to maintain the temperature at or below 10 °C. The mixture was stirred for 3 hours at 0 °C. Excess methylamine and water was evaporated in vacuo and the product was purified by distillation at 103-105 °C, at 0.5 mm Hg, to give the compound 3-Methylamino-1,2-propanediol.

Hazard

3-Methylamino-1,2-propanediol is danger.
H314 (32.76%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H315 (67.24%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (65.52%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

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