Basic information Safety Supplier Related

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2

Basic information Safety Supplier Related

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Basic information

Product Name:
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
Synonyms:
  • PROTEASE-ACTIVATED RECEPTOR-4 AGONIST AMIDE
  • PAR-4 AGONIST AMIDE
  • H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
  • AY-NH2
  • AYPGKFAMIDE
  • AYPGKF-NH2
  • (ALA1)-COAGULATION FACTOR II RECEPTOR-LIKE 3 (1-6) AMIDE (MOUSE)
  • (Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt
CAS:
352017-71-1
MF:
C34H48N8O7
MW:
680.79
Product Categories:
  • peptide
  • Peptide Receptors
  • Proteinase-activated receptor (PAR)
Mol File:
352017-71-1.mol
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H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Chemical Properties

Boiling point:
1143.1±65.0 °C(Predicted)
Density 
1.285±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in H2O
form 
solid
pka
9.84±0.15(Predicted)
color 
White to off-white
Water Solubility 
Soluble in water
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
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H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Usage And Synthesis

Uses

AY-NH2 is used in the synthetic preparation of PAR4 agonist peptides towards PAR4 receptor activation.

Biological Activity

ay-nh2 is a selective agonist of par4 with ec50 value of 11 μm [1].protease-activated receptor-4 (par4) is a member of pars and plays an important role in mediating cellular effects of thrombin through acting g-proteins i, 12/13 (rho and ras activation) and q (calcium signaling) [2].ay-nh2 is a potent par4 agonist and has a higher (~10 fold) activity than gypgkf-nh2. using rat platelet aggregation assay, it was shown that ay-nh2 had highly platelet aggregation ability than gy-nh2 and gf-nh2 [1]. when tested with platelet-rich plasma harvested from wild-type c57bl6 mice, ay-nh2 treatment exhibited highly agonist activity on par4 while had no effect on other pars [3].in male wistar rats model of paw oedema, i.pl. injection of ay-nh2 markedly reduced the nociceptive score in response to both noxious and non-noxious mechanical stimuli, thus inhibiting carrageenan-induced mechanical hyperalgesia and allodynia [4].

storage

Store at -20°C

References

[1]. hollenberg, m.d., et al., proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. br j pharmacol, 2004. 143(4): p. 443-54.
[2]. yu, g., et al., increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. plos one, 2015. 10(4): p. e0122678.
[3]. faruqi, t.r., et al., structure-function analysis of protease-activated receptor 4 tethered ligand peptides. determinants of specificity and utility in assays of receptor function. j biol chem, 2000. 275(26): p. 19728-34.
[4]. asfaha, s., et al., protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. br j pharmacol, 2007. 150(2): p. 176-85.

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