15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER Chemical Properties

solubility 

DMF: >50 mg/ml (from PGE2 methyl es; DMSO: >50 mg/ml (from PGE2 methyl es; Ethanol: >50 mg/ml (from PGE2 methyl es; PBS pH 7.2: 5 mg/ml (from PGE2 methyl este

15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER Usage And Synthesis

Description

15(R)-15-methyl Prostaglandin F_2α methyl ester (15(R)-15-methyl PGF_2α methyl ester) is a lipid soluble prodrug form of 15(R)-15-methyl PGF_2α with increased membrane permeability. Acid-catalyzed epimerization of 15(R)-15-methyl PGF_2α methyl ester and hydrolysis of the ester converts it into the active 15(S)-15-methyl PGF_2α .^1,2

Uses

15(R)-15-Methyl prostaglandin F2α methyl ester (15(R)-Methyl carboprost) (compound 15R) is a 15-methyl substituted prostaglandin analog, a member of the prostaglandin family, with potential biological activities in a variety of biological systems, but its specific activity mechanism and application details are not described in detail from the existing information.

References

1. Plaisted, S.M., DeZwaan, J., and Snider, B.G. High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device J. Chromatogr. 314,369-377(1984).
2. Hamberg, M., Zhang, L.Y., and Bergstr?m, S. On the pH-dependent degradation of 15(S)-15 methyl-prostaglandin F_2α (Carboprost) Eur. J. Pharm. Sci. 3(1),27-38(1995).

15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER(35700-22-2)Related Product Information

• 15(R)-PROSTAGLANDIN F2ALPHA
• 15(R)-15-METHYL PROSTAGLANDIN F2ALPHA
• 15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER