Basic information Safety Supplier Related

15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER

Basic information Safety Supplier Related

15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER Basic information

Product Name:
15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER
Synonyms:
  • 15(R)-15-methyl Prostaglandin F2α methyl ester
  • QQCOAAFKJZXJFP-IFMFXUMGSA-N
  • 15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER
  • 9ALPHA,11ALPHA,15R-TRIHYDROXY-15-METHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID, METHYL ESTER
  • Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, methyl ester, (5Z,9α,11α,13E,15R)-
  • 15(R)-15-methyl Prostaglandin F2α methyl ester
CAS:
35700-22-2
MF:
C22H38O5
MW:
382.53
Mol File:
35700-22-2.mol
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15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER Chemical Properties

solubility 
DMF: >50 mg/ml (from PGE2 methyl es; DMSO: >50 mg/ml (from PGE2 methyl es; Ethanol: >50 mg/ml (from PGE2 methyl es; PBS pH 7.2: 5 mg/ml (from PGE2 methyl este
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15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER Usage And Synthesis

Description

15(R)-15-methyl Prostaglandin F methyl ester (15(R)-15-methyl PGF methyl ester) is a lipid soluble prodrug form of 15(R)-15-methyl PGF with increased membrane permeability. Acid-catalyzed epimerization of 15(R)-15-methyl PGF methyl ester and hydrolysis of the ester converts it into the active 15(S)-15-methyl PGF .1,2

References

1. Plaisted, S.M., DeZwaan, J., and Snider, B.G. High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device J. Chromatogr. 314,369-377(1984).
2. Hamberg, M., Zhang, L.Y., and Bergstr?m, S. On the pH-dependent degradation of 15(S)-15 methyl-prostaglandin F (Carboprost) Eur. J. Pharm. Sci. 3(1),27-38(1995).

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15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER(35700-22-2)Related Product Information