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2-Adamantanamine hydrochloride

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2-Adamantanamine hydrochloride Basic information

Product Name:
2-Adamantanamine hydrochloride
Synonyms:
  • tricyclo(3.3.1.1(sup3,7))decan-2-amine,hydrochloride
  • 2-ADAMANTYLAMINE HYDROCHLORIDE
  • 2-ADAMANTANAMINE HYDROCHLORIDE
  • 2-AMINOADAMANTANE HYDROCHLORIDE
  • 2-Adamantamine hydrochloride 98+%
  • tricyclo(3.3.1.13.7)dec-2-ylamine hydrochloride
  • adamantan-2-amine hydrochloride
  • 2-ADAMANTANAMINE HCL
CAS:
10523-68-9
MF:
C10H18ClN
MW:
187.71
EINECS:
234-074-2
Product Categories:
  • Adamantanes
  • Adamantane derivatives
Mol File:
10523-68-9.mol
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2-Adamantanamine hydrochloride Chemical Properties

Melting point:
>300 °C(lit.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Crystalline Powder
color 
White
Water Solubility 
soluble
BRN 
4297901
InChI
InChI=1/C10H17N.ClH/c11-10-8-2-6-1-7(4-8)5-9(10)3-6;/h6-10H,1-5,11H2;1H/t6-,7+,8-,9+,10?;
InChIKey
WLDWDRZITJEWRJ-ZDAMNCSYNA-N
SMILES
C1(N)[C@@]2([H])C[C@]3([H])C[C@]([H])(C2)C[C@@]1([H])C3.Cl |&1:2,5,8,12,r|
CAS DataBase Reference
10523-68-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-36/37/39-22
WGK Germany 
3
RTECS 
AU4375100
10
HazardClass 
IRRITANT
HS Code 
29213000

MSDS

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2-Adamantanamine hydrochloride Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2?-(carboxymethoxime)-olivomycin I. The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Uses

2-Adamantanamine Hydrochloride can be used to prepare CD73 inhibitors to treat CD73-associated diseases, including cancer and immune-related disorders.

General Description

The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied.

Purification Methods

The free amine in Et2O, liberated by the action of alkali in H2O, is dried over KOH, filtered, evaporated and sublimed at 110o/12torr, m 230-236o. The base is dissolved in EtOH, sufficient ethanolic HCl is added dropwise and crystallised by the addition of Et2O. Dry it in vacuo. [Stetter et al. Justus Liebigs Ann Chem 658 151 1962].

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