2-Adamantanamine hydrochloride Chemical Properties

Melting point:

>300 °C(lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Crystalline Powder

color 

White

Water Solubility 

soluble

BRN 

4297901

InChI

InChI=1/C10H17N.ClH/c11-10-8-2-6-1-7(4-8)5-9(10)3-6;/h6-10H,1-5,11H2;1H/t6-,7+,8-,9+,10?;

InChIKey

WLDWDRZITJEWRJ-ZDAMNCSYNA-N

SMILES

C1(N)[C@@]2([H])C[C@]3([H])C[C@]([H])(C2)C[C@@]1([H])C3.Cl |&1:2,5,8,12,r|

CAS DataBase Reference

10523-68-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36-36/37/39-22

WGK Germany 

3

RTECS 

AU4375100

F 

10

HazardClass 

IRRITANT

HS Code 

29213000

MSDS

• Language:English Provider:2-Aminoadamantane hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Adamantanamine hydrochloride Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2?-(carboxymethoxime)-olivomycin I. The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Uses

2-Adamantanamine Hydrochloride can be used to prepare CD73 inhibitors to treat CD73-associated diseases, including cancer and immune-related disorders.

General Description

The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied.

Purification Methods

The free amine in Et2O, liberated by the action of alkali in H2O, is dried over KOH, filtered, evaporated and sublimed at 110o/12torr, m 230-236o. The base is dissolved in EtOH, sufficient ethanolic HCl is added dropwise and crystallised by the addition of Et2O. Dry it in vacuo. [Stetter et al. Justus Liebigs Ann Chem 658 151 1962].

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