acetyl carbromal Chemical Properties

Melting point:

108-109°

Density 

1.5941 (rough estimate)

refractive index 

1.5190 (estimate)

EPA Substance Registry System

Butanamide, N-[(acetylamino)carbonyl]-2-bromo-2-ethyl- (77-66-7)

acetyl carbromal Usage And Synthesis

Originator

Acetylcarbromal ,Pfaltz and Bauer

Definition

ChEBI: Acecarbromal is a N-acylurea.

Manufacturing Process

It was mixed 120 parts of urea and 258 parts of bromodiethylacetylbromide (prepared from diethylacetic acid anhydride and bromine). After 12 hours the mixture was heated for 3 hours at 100°C. The product was mixed with an aqueous solution of sodium bicarbonate and then was filtered. The obtained bromodiethylacetylurea was crystallized from diluted ethanol; melting point 114-118°C. The mixture of 474 parts of bromodiethylacetylurea, 1000 parts of acetic anhydride and 75 parts ZnCl2 was heated at 60°C for 1 hour. The product was stirred with 3000 parts of ice-water and then 1-acetyl-3-(α- bromo-α-ethylbutyryl)urea was filtered; melting point 108-109°C.

Therapeutic Function

Sedative, Hypnotic

acetyl carbromal(77-66-7)Related Product Information

• ACETYLUREA
• Acetyl bromide
• 2-BROMO-2-METHYLPROPANAMIDE
• 2-BROMOPROPIONAMIDE
• acetyl carbromal
• N,N'-methylenediacetamide
• (2-BROMO-2-ETHYLBUTYRYL)UREA
• 2-BROMO-2-METHYL-PROPIONALDEHYDE
• 3-BROMO-3-METHYLPENTANE
• 2-BROMOBUTYRAMIDE
• 2-BROMO-2-METHYLBUTANE
• 2-BROMO-ISONICOTINIC ACID METHYL ESTER
• 3-BROMOPENTANE