4-CHLORO-3-FLUOROANISOLE Chemical Properties

Boiling point:

200-204°C

Density 

1.26

refractive index 

1.516-1.518

Flash point:

60.8±21.8℃

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow

CAS DataBase Reference

501-29-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

RIDADR 

1993

Hazard Note 

Irritant

HS Code 

2909309090

MSDS

• Language:English Provider:ACROS

4-CHLORO-3-FLUOROANISOLE Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS LIQUID

Synthesis

To a solution of acetone (10 mL) containing 4-chloro-3-fluorophenol (500 mg, 3.41 mmol) was added potassium carbonate (942.59 mg, 6.82 mmol) and iodomethane (1.94 g, 13.64 mmol). The reaction mixture was stirred at 60 °C for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether:ethyl acetate = 20:1) to confirm the completion of the reaction. After completion of the reaction, the mixture was concentrated to remove the solvent. Water (20 mL) was added to the residue and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 4-chloro-3-fluoroanisole (470 mg, 2.93 mmol, 85.84% yield) as a colorless oil.

References

[1] Patent: CN105330698, 2016, A. Location in patent: Paragraph 0593; 0594; 0595; 0596
[2] Patent: WO2011/56652, 2011, A1. Location in patent: Page/Page column 118-119

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