5-Methyl-1,3,4-oxadiazol-2(3H)-one Chemical Properties

Melting point:

112 °C

Boiling point:

134 °C(Press: 14 Torr)

Density 

1.55±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

6.34±0.70(Predicted)

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HazardClass 

IRRITANT

5-Methyl-1,3,4-oxadiazol-2(3H)-one Usage And Synthesis

Chemical Properties

This product is solid and insoluble in water.

Synthesis

(2) Preparation of 5-methyl-1,3,4-oxadiazolone: 2000 mL of methyl acetate was added to a 5000 mL three-necked flask and 740 g of acetylhydrazine was added slowly under stirring conditions. The reaction mixture was cooled to below 0 °C, followed by the addition of 1680 g of sodium bicarbonate in batches. The reaction unit was sealed and the phosgene was continuously vented at a flow rate of 15 m3/h. After completion of the reaction, the solvent was removed by distillation and the resulting residue was crystallized at 0 °C. The white crystals were collected by filtration to give 988.2 g of the target product in 99% yield.

References

[1] Patent: CN103724327, 2017, B. Location in patent: Paragraph 0008; 0030; 0032