2’-O-Methyl-rA(N-Bz)phosphoramidite Chemical Properties

Melting point:

93-95°C

storage temp. 

Sealed in dry,2-8°C

solubility 

Acetonitrile (Sparingly), DMSO (Slightly), Methanol (Slightly)

form 

powder

pka

7.87±0.43(Predicted)

color 

white to off-white

InChI

InChI=1/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/s3

InChIKey

AZCGOTUYEPXHMJ-DCATYJMPNA-N

SMILES

O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,49,r|

Safety Information

WGK Germany 

3

HS Code 

29349990

2’-O-Methyl-rA(N-Bz)phosphoramidite Usage And Synthesis

Chemical Properties

White or off-white power

Uses

(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a nucleotide used in the synthesis of native-like crosslinked duplex RNA.

General Description

Proligo′s 2′O-Methyl RNA monomers are compatible with fast deprotectionschemes that are based on the application of aliphatic amines, such asmethylamine. The adenosine and guanosine monomers are protected bythe standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl RNA is a nucleic acid analog that is characterized by theexceptional hybridization properties that it imparts with complimentary DNA or RNA, as well as increased stability against enzymatic degradationcompared to natural nucleic acids.The unique combination of properties of 2′O-Methyl RNA had foundwidespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

2’-O-Methyl-rA(N-Bz)phosphoramidite(110782-31-5)Related Product Information

• DMT-dG(dmf) Phosphoramidite
• DMT-2′O-Methyl-rC(ac) Phosphoramidite
• 2'-O-Methylcytidine
• DMT-2μ-O-Me-rG(ib) amidite
• DMT-2′Fluoro-dU Phosphoramidite
• 2'-O-MOE-A(Bz)-3'-phosphoramidite
• 2'-O-(2-Methoxyethyl)-5-methyluridine
• N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite
• N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite
• Dmt-2'-f-dc(ac) amidite
• 2'-O-(2-Methoxyethyl)cytidine
• 2'-O-Methylguanosine
• 2'-O-(2-Methoxyethyl)uridine
• DMT-2'-O-MOE-rU Phosphoramidite
• 2'-O-MOE-ADENOSINE
• 2'-OMe-ibu-G Phosphoramidite
• 2'-O-(2-Methoxyethyl)guanosine
• 2'-O-Methyladenosine