Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Nucleoside drugs >  2’-O-Methyl-rA(N-Bz)phosphoramidite

2’-O-Methyl-rA(N-Bz)phosphoramidite

Basic information Safety Supplier Related

2’-O-Methyl-rA(N-Bz)phosphoramidite Basic information

Product Name:
2’-O-Methyl-rA(N-Bz)phosphoramidite
Synonyms:
  • 2’-O-Methyl-rA(N-Bz)phosphoramidite
  • N-blocked-5'-O-DMT-2'-O-Me CED adenosine phosphoramidite
  • 5'-O-DMT-2'-O-Me-rA(N-Bz)-3'-CEDPA
  • N-Benzoyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methyladenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 2'-OMe-Bz-A Phosphoramidite
  • Ac-dA Phosphoramidite
  • 5'-O-DMT-2'-O-Me-A(bz) phosphoramidite
  • 2'OMe-A CE PhosphoraMidite
CAS:
110782-31-5
MF:
C48H54N7O8P
MW:
887.96
EINECS:
200-100-5
Product Categories:
  • Amidite
Mol File:
110782-31-5.mol
More
Less

2’-O-Methyl-rA(N-Bz)phosphoramidite Chemical Properties

Melting point:
93-95°C
storage temp. 
Sealed in dry,2-8°C
solubility 
Acetonitrile (Sparingly), DMSO (Slightly), Methanol (Slightly)
form 
powder
pka
7.87±0.43(Predicted)
color 
white to off-white
InChI
InChI=1/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/s3
InChIKey
AZCGOTUYEPXHMJ-DCATYJMPNA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,49,r|
More
Less

Safety Information

WGK Germany 
3
HS Code 
29349990
More
Less

2’-O-Methyl-rA(N-Bz)phosphoramidite Usage And Synthesis

Chemical Properties

White or off-white power

Uses

(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a nucleotide used in the synthesis of native-like crosslinked duplex RNA.

General Description

Proligo′s 2′O-Methyl RNA monomers are compatible with fast deprotectionschemes that are based on the application of aliphatic amines, such asmethylamine. The adenosine and guanosine monomers are protected bythe standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl RNA is a nucleic acid analog that is characterized by theexceptional hybridization properties that it imparts with complimentary DNA or RNA, as well as increased stability against enzymatic degradationcompared to natural nucleic acids.The unique combination of properties of 2′O-Methyl RNA had foundwidespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

2’-O-Methyl-rA(N-Bz)phosphoramiditeSupplier

Nugene Biopharm Science (Hangzhou) Co., Ltd. Gold
Tel
13326014885
Email
service@nugene.com.cn
Shanghai Peinuo Biotechnology Co., Ltd Gold
Tel
021-58648778 18217200601
Email
bush@perno.cn
Wuhu Nuowei Chemical Technology Co., Ltd Gold
Tel
0553-8233716 18055326116
Email
kendoll@cqpharm.com
Nanjing F&S Pharmatech Co., Ltd. Gold
Tel
025-86950358 13390612682
Email
wangjinyu@fshpharm.com
Wuhu Huaren Science and Technology Co., Ltd. Gold
Tel
0553-0553-0553-5842013-801-801 18155347026
Email
jinhuaren@huarensh.com