6-Bromo-5-fluoroindole Chemical Properties

Melting point:

82-84 °C

Boiling point:

315.9±22.0 °C(Predicted)

Density 

1.750

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

solid

pka

15.23±0.30(Predicted)

Appearance

Light yellow to brown Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

WGK Germany 

3

6-Bromo-5-fluoroindole Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-fluoro-6-bromoindole from the compound (CAS:1034894-73-9): enamine (1.89 g, 4.38 mmol) was dissolved in ethanol (35.0 mL). To this solution, iron powder (4.42 g, 79.0 mmol) and acetic acid (35.0 mL) were added, and the reaction mixture was stirred at 90 °C overnight. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography (eluent: ethyl acetate/hexane, 1:9, v/v) to afford 6-bromo-5-fluoro-1H-indole as a yellow solid (0.83 g, 89% yield).1H NMR (CDCl3, 400 MHz) δ: 6.52 (m, 1H), 7.27 (m, 1H), 7.38 (d, J = 9.3 Hz, 1H) 7.57 (d, J = 5.7 Hz, 1H), 8.18 (br.s, 1H).

References

[1] Patent: WO2008/77138, 2008, A1. Location in patent: Page/Page column 77
[2] Patent: US2004/224973, 2004, A1. Location in patent: Page 22

6-Bromo-5-fluoroindole(259860-08-7)Related Product Information

• 5-Fluoroindole
• 6-Bromo-5-fluoroindole
• 6-BroMo-5-chloro-7-azaindole
• 6-bromo-5-methoxy-1H-indole
• 1H-Indole, 6-broMo-7-fluoro-
• 6-BROMO-7-METHYLINDOLE
• 6-BroMo-5-fluoro-7-azaindole