PROGLUMETACIN MALEATE Chemical Properties

solubility 

DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

form 

Solid

color 

White to Pale Yellow

PROGLUMETACIN MALEATE Usage And Synthesis

Uses

Proglumetacin Dioxalate is a new non-steroidal anti-inflammatory drug.

Definition

ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropy -alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretor effects that helps prevent injury to the stomach lining.

Synthesis

The reaction of N-benzoyl-N_x0002_, N_x0002_-di-n-propyl-dl-isoglutamin (proglumide) with 1-(3-chloropropyl)-4-(2-hydroxyethyl)-piperazine obtained from 1-(2-hydroxyethyl)piperazine and 1-bromo-3-chloropropane by means of sodium methanolate in DMSO at 105?C gives N--N_x0002_-(2-hydroxyethyl) piperazine, which is then condensated with Indomethacin (1-(p-chlorobenzoyl)- 5-methoxy-2-methylindole-3-acetic acid) by means of dicyclohexylcabodiimide and NaHCO3 in ethyl acetate .

PROGLUMETACIN MALEATE(57132-53-3)Related Product Information

• Ethyl 3-indoleacetate
• PROGLUMETACIN MALEATE
• 5-Methoxyindole-3-acetic acid
• 1-METHYL-3-INDOLEACETIC ACID
• 5-HYDROXYINDOLE-3-ACETIC ACID
• 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID
• 2-METHYLINDOLE-3-ACETIC ACID
• Indometacin
• Delmetacin
• 5-HYDROXYTRYPTOPHOL
• 5-METHOXYTRYPTOPHOL
• Proglumide
• 1-Acetyl-5-methoxyindole
• 1-[2-(1-PROPYL)-OXYETHYL]-PIPERAZINE
• 1-Ethyl-5-methoxyindole
• 1-METHYLINDOLE-3-ACETIC ACID ETHYL ESTER
• ETHYL 2-METHYL-3-INDOLEACETATE
• (5-METHOXY-2-METHYL-1H-INDOL-3-YL)-ACETIC ACID ETHYL ESTER