Basic information Safety Supplier Related

PROGLUMETACIN MALEATE

Basic information Safety Supplier Related

PROGLUMETACIN MALEATE Basic information

Product Name:
PROGLUMETACIN MALEATE
Synonyms:
  • PROGLUMETACIN
  • PROGLUMETACIN MALEATE
  • Proglumetacine
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester (9CI)
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester, (+-)-
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl ester
CAS:
57132-53-3
MF:
C46H58ClN5O8
MW:
844.43
Mol File:
57132-53-3.mol
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PROGLUMETACIN MALEATE Chemical Properties

solubility 
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
Solid
color 
White to Pale Yellow
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PROGLUMETACIN MALEATE Usage And Synthesis

Uses

Proglumetacin Dioxalate is a new non-steroidal anti-inflammatory drug.

Definition

ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropy -alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretor effects that helps prevent injury to the stomach lining.

Synthesis

The reaction of N-benzoyl-N_x0002_, N_x0002_-di-n-propyl-dl-isoglutamin (proglumide) with 1-(3-chloropropyl)-4-(2-hydroxyethyl)-piperazine obtained from 1-(2-hydroxyethyl)piperazine and 1-bromo-3-chloropropane by means of sodium methanolate in DMSO at 105?C gives N--N_x0002_-(2-hydroxyethyl) piperazine, which is then condensated with Indomethacin (1-(p-chlorobenzoyl)- 5-methoxy-2-methylindole-3-acetic acid) by means of dicyclohexylcabodiimide and NaHCO3 in ethyl acetate .

in vivo

Proglumetacin (Sprague-Dawley rats, 0-30 mg/kg, Orally, once) dose-dependently inhibits accumulation of pouch exudate[1].

Animal Model:Sprague-Dawley rats (6 weeks)
Dosage:0, 0.3, 3, 9, 30 mg/kg
Administration:Orally, once
Result:Caused dose-dependent reduction of leukocyte migration into the pouch exudate, caused 49.2% inhibition at 30 mg/kg; and markedly decreased the prostaglandin E2 content of the pouch exudate, but tended to increase the leukotriene B 4 content.

PROGLUMETACIN MALEATESupplier

J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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jkinfo@jkchemical.com
Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
Email
sales@chemreagents.com
Hangzhou Yuhao Chemical Technology Co., Ltd
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0571-82693216
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info@yuhaochemical.com
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
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