Pranoprofen Chemical Properties

Melting point:

182-183°

Boiling point:

398.5°C (rough estimate)

Density 

1.1654 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

4.27±0.10(Predicted)

form 

powder

color 

white to beige

CAS DataBase Reference

52549-17-4(CAS DataBase Reference)

Safety Information

RIDADR 

UN 2811 6.1 / PGIII

RTECS 

DJ3100950

Toxicity

LD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga)

Pranoprofen Usage And Synthesis

Chemical Properties

Off-White Solid

Originator

Niflan, Yoshitomi ,Japan ,1981

Uses

Pranoprofen is an anti-inflammatory used in ophthalmology.

Definition

ChEBI: Pranoprofen is a pyridochromene.

Manufacturing Process

A mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C.

Therapeutic Function

Analgesic, Antiinflammatory

General Description

Pranoprofen is an arylalkanoic acid and a non-steroidal anti-inflammatory drug.

Biochem/physiol Actions

Pranoprofen is used in eyes to treat chronic allergic conjunctivitis. It is also used as an anti-inflammatory and analgesic drug after strabismus surgery.

Pranoprofen(52549-17-4)Related Product Information

• Centchroman
• Imidocarb dipropionate
• Folic acid
• Propionic acid
• Nandrolone phenylpropionate
• 3-(4-Hydroxyphenyl)propionic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• 3-Phenylpropionic acid
• Ascoric Acid
• Ibuprofen
• N,N-dimethylcarbamoylmethyl alpha,2-dimethyl-5H-1-benzopyrano(2,3-b)pyridine-7-acetate
• ALFA-METHYL-5H-[1] BENZOPYRANO [2,3-B] PYRIDINE-7-ACETIC ACID ETHYL ESTER
• 4-METHOXY-3-METHYLPHENYLACETIC ACID
• Pranoprofen
• l-Pranoprofen,(S)-(+)-Pranoprofen
• (R)-Pranoprofen,(R)-(-)-Pranoprofen,d-Pranoprofen
• 2-(4-METHOXY-3-METHYLPHENYL)ACETALDEHYDE
• ALFA-METHYL-ALFA-CYANO-5H-[1] BENZOPYRANO [2,3-B] PYRIDINE-7-ACETIC ACID ETHYL ESTER