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Pranoprofen

Basic information Safety Supplier Related

Pranoprofen Basic information

Product Name:
Pranoprofen
Synonyms:
  • PRANOPROFEN
  • (RS)-Pranoprofen
  • 5H-[1]Benzopyrano[2,3-b]pyridine-7-acetic acid, a-methyl- (9CI)
  • a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-ylacetic acid
  • dl-Pranoprofen
  • Niflan
  • Y 8004
  • pyranoprofen
CAS:
52549-17-4
MF:
C15H13NO3
MW:
255.27
EINECS:
682-035-7
Product Categories:
  • NIFLAN
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • >97%,BR
Mol File:
52549-17-4.mol
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Pranoprofen Chemical Properties

Melting point:
182-183°
Boiling point:
398.5°C (rough estimate)
Density 
1.1654 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
pka
4.27±0.10(Predicted)
form 
powder
color 
white to beige
CAS DataBase Reference
52549-17-4(CAS DataBase Reference)
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Safety Information

RIDADR 
UN 2811 6.1 / PGIII
RTECS 
DJ3100950
Toxicity
LD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga)
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Pranoprofen Usage And Synthesis

Chemical Properties

Off-White Solid

Originator

Niflan, Yoshitomi ,Japan ,1981

Uses

Pranoprofen is an anti-inflammatory used in ophthalmology.

Manufacturing Process

A mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C.

Therapeutic Function

Analgesic, Antiinflammatory

PranoprofenSupplier

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