4-Chloro-2,6-diaminopyrimidine Chemical Properties

Melting point:

199-202 °C(lit.)

Boiling point:

199-202 °C

Density 

1.3966 (rough estimate)

vapor pressure 

0.0±1.1 mmHg at 25°C

refractive index 

1.702

Flash point:

218.9±29.6 °C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

slightly soluble

pka

3.66±0.10(Predicted)

form 

Solid

color 

White to Pale Yellow

Water Solubility 

slightly soluble

BRN 

118455

InChI

InChI=1S/C4H5ClN4/c5-2-1-3(6)9-4(7)8-2/h1H,(H4,6,7,8,9)

InChIKey

QJIUMVUZDYPQRT-UHFFFAOYSA-N

SMILES

C1(N)=NC(Cl)=CC(N)=N1

CAS DataBase Reference

156-83-2(CAS DataBase Reference)

NIST Chemistry Reference

Pyrimidine, 6-chloro-2,4-diamino-(156-83-2)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29335995

MSDS

• Language:English Provider:4-Chloro-2,6-diaminopyrimidine
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4-Chloro-2,6-diaminopyrimidine Usage And Synthesis

Chemical Properties

White Cyrstalline Solid

Uses

Melamine and Related Compounds in Dog Food Using GC-MS

Definition

ChEBI: 6-chloro-2,4-pyrimidinediamine (4-Chloro-2,6-diaminopyrimidine) is a member of pyrimidines and an organohalogen compound.

Synthesis

2,4-Diamino-6-hydroxypyrimidine (1.00 g, 7.93 mmol) was added to POCl3 (9 mL) and stirred at 97 ℃ for 17 h. The reaction solution was added to ice water slowly and then stirred at 90 C for 1 h. The pH of this solution was adjusted to 8 with NaOH, and then it was extracted with EtOAC (150 mL 3). The combined organic layers were dried with Na2SO4, filtered, and concentrated to give white solid 4-Chloro-2,6-diaminopyrimidine 0.97 g, yielding 85%.

Purification Methods

It recrystallises from boiling H2O (charcoal) as needles; it also crystallises from Me2CO. [Büttner Chem Ber 36 2232 1903, Roth J Am Chem Soc 72 1914 1950, UV: Brown & Jacobsen J Chem Soc 3172 1962, Beilstein 24 H 318, 25 III/IV 2788.]

4-Chloro-2,6-diaminopyrimidine(156-83-2)Related Product Information

• Iminodiacetonitrile
• 1,3-Diaminoguanidine monohydrochloride
• 4,6-Dihydroxypyrimidine
• Iminodiacetic acid
• Diaminomaleonitrile
• 4-Amino-6-chloropyrimidine
• 2,4-Dichloropyrimidine
• HYDRAZINE
• 4,4'-Methylenedianiline
• Difluorochloromethane
• 4-Chloro-2,6-Diaminopyrimidine-N-Oxide,6-Chloro-2,4-diaminopyrimidine-N-oxide
• 4-CHLORO-6-MORPHOLIN-4-YLPYRIMIDIN-2-AMINE
• 6-CHLORO-N4,N4-DIETHYLPYRIMIDINE-2,4-DIAMINE
• 4-CHLORO-5,6-DIAMINOPYRIMIDINE,6-Chloro-4,5-diaminopyrimidine
• 2-CHLORO-4,5-DIAMINOPYRIMIDINE
• 4-Chloropyrimidine
• Minoxidil
• 6-CHLORO-N4,N4-DIPROPYL-2,4-PYRIMIDINEDIAMINE