N-Isopropylbenzylamine Chemical Properties

Melting point:

143°C (estimate)

Boiling point:

200 °C(lit.)

Density 

0.892 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.502(lit.)

Flash point:

190 °F

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), Ethy Acetate (Slightly), Methanol (Slightly)

pka

9.77±0.19(Predicted)

form 

Oil

color 

Colourless

BRN 

2638437

InChIKey

LYBKPDDZTNUNNM-UHFFFAOYSA-N

CAS DataBase Reference

102-97-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanamine, N-(1-methylethyl)-(102-97-6)

EPA Substance Registry System

Benzenemethanamine, N-(1-methylethyl)- (102-97-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

2735

WGK Germany 

3

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29214980

MSDS

• Language:English Provider:N-(1-Methylethyl)-benzenemethanamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-Isopropylbenzylamine Usage And Synthesis

Chemical Properties

CLEAR VERY SLIGHTLY YELLOW TO YELLOW LIQUID

Uses

N-Isopropylbenzylamine, can be used as an intermediate in the synthesis of pharmaceutical compounds,and as a precursor to the manufacture of some drugs. Due to it’s similarity in appearance and physical properties to methamphetamine, it has been recently come under consideration of DEA.

Preparation

N-benzylisopropylamine is synthesized by the reduction reaction of N-isopropylbenzamide or prepared from benzylamine and acetone by reductive amination reaction.

Application

N-Isopropylbenzylamine was used as ligand in the preparation and characterization of bis(cyclopentadienyl)magnesium. It was also used in the synthesis of N-benzylideneisopropylamine-N-oxide.

General Description

N-isopropylbenzylamine is a structural isomer of methamphetamine, is one of the most common adulterants. It forms amine adducts with magnesocene at ambient temperature in toluene.

Cytotoxicity

The toxicity of N-isopropylbenzylamine was evaluated in SH-SY5Y, PC12, and SN4741 cell lines. Cells were treated with 0.3–10 mM N-isopropylbenzylamine for 24 hours, and cell viability was measured using MTT assay. N-isopropylbenzylamine concentration-dependently reduced cell viability in these cells. The IC50 values of N-isopropylbenzylamine on cell viability were 3.47, 1.49, and 3.21 mM for SH-SY5Y cells, PC12 cells, and SN4741 cells, respectively. N-isopropylbenzylamine produced toxicity in cell lines that model neurons. Moreover, the activation of nNOS and the production of intracellular NO might be involved in N-isopropylbenzylamine-induced toxicity in SN4741 cells[1].

References

[1] Peng Xu . “N-isopropylbenzylamine, a methamphetamine mimics, produces toxicity via increasing nitric oxide in vitro.” Toxicology 480 (2022): Article 153337.

N-Isopropylbenzylamine(102-97-6)Related Product Information

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• N-Isopropylbenzylamine
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• Metrizamide
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• 1-METHYL-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER
• Methyl N-methyl piperidine-4-carboxylate
• Isopropylamine
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• (S)-(-)-1-BENZYL-2-PYRROLIDINEMETHANOL