1,3,5-Triazine Chemical Properties

Melting point:

77-83 °C (dec.)(lit.)

Boiling point:

114°C

Density 

1,38 g/cm³

refractive index 

1.5060 (estimate)

Flash point:

114°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

methanol: 0.1 g/mL, clear

pka

2.07±0.10(Predicted)

form 

powder to crystal

color 

White to Orange to Green

Sensitive 

Moisture Sensitive

Merck 

14,9602

BRN 

104790

CAS DataBase Reference

290-87-9(CAS DataBase Reference)

NIST Chemistry Reference

1,3,5-Triazine(290-87-9)

Safety Information

Hazard Codes 

Xn,C

Risk Statements 

22-37/38-41-34

Safety Statements 

22-24/25-39-26-45-36/37/39-27

RIDADR 

UN2928

WGK Germany 

3

RTECS 

XY2957000

HazardClass 

6.1

PackingGroup 

II

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,3,5-Triazine Usage And Synthesis

Chemical Properties

White crystal

Application

1,3,5-Triazine is a useful replacement for HCN in the Gattermann reaction for the synthesis of aromatic aldehydes. It reacts with nucleophiles, e.g. amines, which is utilized in quinazoline synthesis.

Uses

1,3,5-Triazine is a reagent in oxidation reactions, in synthesis of heterocycles. Triazine derivatives are used as herbicides, pharmaceuticals, complexation agents, peptidomimetic building blocks, and dyes.

Definition

1,3,5-Triazine, also known as s-triazine, is a six-membered ring organic compound, which is one of the isomers of triazine.

Preparation

Symmetrical 1,3,5-triazines are prepared by trimerization of certain nitriles such as cyanogen chloride or cyanimide. Benzoguanamine (with one phenyl and 2 amino substituents) is synthesised from benzonitrile and dicyandiamide. In the Pinner triazine synthesis (named after Adolf Pinner) the reactants are an alkyl or aryl amidine and phosgene. Insertion of an N-H moiety into a hydrazide by a copper carbenoid, followed by treatment with ammonium chloride also gives the triazine core.
Amine-substituted triazines called Guanamines are prepared by the condensation of cyanoguanidine with the corresponding nitrile:
(H2N)2C=NCN + RCN → (CNH2)2(CR)N3

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