3′,4′-(Methylenedioxy)propiophenone Chemical Properties

Melting point:

34-36°C

Boiling point:

165-168°C 20mm

Density 

1,21 g/cm³

Flash point:

165-168°C/20mm

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Low-Melting Solid

color 

Off-White to Light Brown

BRN 

165729

InChI

InChI=1S/C10H10O3/c1-2-8(11)7-3-4-9-10(5-7)13-6-12-9/h3-5H,2,6H2,1H3

InChIKey

RVBJGSPBFIUTTR-UHFFFAOYSA-N

SMILES

C(C1=CC=C2OCOC2=C1)(=O)CC

CAS DataBase Reference

28281-49-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

33-22

Safety Statements 

26-37

RTECS 

UC0440600

MSDS

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3′,4′-(Methylenedioxy)propiophenone Usage And Synthesis

Description

3′,4′-(Methylenedioxy)propiophenone, also known as 3,4-(Methylenedioxy)phenyl-1-propanone (MDP1P), is a member of the benzodioxole family, which is a five-membered heterocyclic compound. This compound is a phenylpropanoid found in some plants of the genus Piper and is an isomer of 3,4-methylenedioxyphenyl-2-propanone (MDP2P).

Chemical Properties

Pale Orange Solid

Uses

Intermediate in the production of Isosafrole and Ethylone.

Definition

ChEBI: 3,4-Methylenedioxypropiophenone is a member of benzodioxoles.

Application

3′,4′-(Methylenedioxy)propiophenone is a synthetic compound with a fatty acid chain. It has been shown to have potent activity against leishmania and has been used as an intermediate in the synthesis of other drugs. 3′,4′-(Methylenedioxy)propiophenone can be synthesized by acylation reactions with chloride and acetylcholinesterase inhibition. This product also has molecular docking properties, which have been analyzed using computational methods, such as profiling and profile analysis.

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 3085, 1982 DOI: 10.1016/S0040-4039(00)87539-5

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