N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Chemical Properties

Boiling point:

56-57 °C (lit.)

Density 

1.230 g/mL at 25 °C (lit.)

refractive index 

1.3460

Flash point:

56-57°C/58mm

storage temp. 

Flammables area

solubility 

soluble in Acetone,Ether

pka

1.50±0.70(Predicted)

form 

Liquid

color 

Clear colorless to yellow

Specific Gravity

1.230

Merck 

14,5108

InChI

1S/C7H11F6N/c1-3-14(4-2)7(12,13)5(8)6(9,10)11/h5H,3-4H2,1-2H3

InChIKey

BNTFCVMJHBNJAR-UHFFFAOYSA-N

SMILES

CCN(CC)C(F)(F)C(F)C(F)(F)F

CAS DataBase Reference

309-88-6(CAS DataBase Reference)

EPA Substance Registry System

N,N-Diethyl-2H-perfluoropropanamine (309-88-6)

Safety Information

Hazard Codes 

C

Risk Statements 

10-34

Safety Statements 

16-26-36/37/39-45

RIDADR 

3267

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

II

HS Code 

29211999

Storage Class

3 - Flammable liquids

Hazard Classifications

Flam. Liq. 3
Skin Corr. 1B

MSDS

• Language:English Provider:N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
• Language:English Provider:ALFA

N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Usage And Synthesis

Chemical Properties

Clear colorless to yellow liquid

Uses

Demonstrates utility in fluorination.7

Uses

Reactant for:

• Friedel-Crafts type arylation of hydrofluorocarbons
• Microbial hydroxylation of antibiotics
• Electrochemical fluorination of trialkylamines and tetraalkylammonium salts
• Fluorination of pyrethroides

• γ-Hydroxy-α-fluoro-α-trifluoromethylcarboxamide
• Florfenicol and thiamphenicol

Uses

Fluorinating agent.

General Description

GC analysis includes Et₂NCF=CFCF₃ (two isomers), both of which are active fluorinating agents.

Synthesis

N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine is prepared as follows: take 600-700 portions of dichloromethane, add 65-85 portions of diethylamine, lower the temperature to -5 ?? to -25 ??, pass 110 portions of -165 portions of hexafluoropropylene after the reaction for 1h. 165 portions of hexafluoropropylene, pass through the reaction after 1h, get fluoride reagent standby; the addition amount of diethylamine is preferably 75-80 portions, the addition amount of hexafluoropropylene is preferably 160-165 portions.

N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine(309-88-6)Related Product Information

• 2-Aminoethyl(ethyl)amine
• N,N-Diethylaniline
• N-Ethylcarbazole
• Diethyl malonate
• Hexafluoroethane
• Isopropylamine
• Diethyl phthalate
• Diisopropylammonium dichloroacetate
• (-)-2-[METHYLAMINO]-1-PHENYLPROPANE
• Celiprolol
• D/L-AMPHETAMINE HYDROCHLORIDE
• Perfluorotripropylamine
• Diethyl ether
• TRIETHYLAMINE PENTAHYDROFLUORIDE
• 3,3,3-TRIFLUOROPROPYLAMINE
• DIFLUOROMETHYLDIMETHYLAMINE
• N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
• SALOR-INT L173401-1EA