RUBOXISTAURIN HYDROCHLORIDE Chemical Properties

alpha 

D25 -28.7° (c = 1.0 in ethanol)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO: soluble10mg/mL, clear

form 

powder

color 

orange-red

Safety Information

WGK Germany 

3

RUBOXISTAURIN HYDROCHLORIDE Usage And Synthesis

Description

LY333531 is an inhibitor of PKCβ (IC₅₀s = 4.7 and 5.9 nM for PKCβ1 and PKCβ2, respectively). It is selective for PKCβ1 and PKCβ2 over PKCα, -γ, -δ, -ε, -ζ, and -η (IC₅₀s = 360, 300, 250, >100,000, and 52 nM, respectively). LY333531 also inhibits glycogen synthase kinase 3β (GSK3β; IC₅₀ = 39.4 nM). It inhibits neutrophil extracellular trap (NET) formation induced by phorbol 12-myristate 13-acetate (PMA; ) in primary human neutrophils when used at a concentration of 1 μM. LY333531 increases the mechanical nociceptive threshold in a rat model of diabetic hyperalgesia induced by streptozotocin (STZ; ).

Uses

A protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). It is used in treatment of diabetic microvascular comp

Uses

Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.

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