4-(Trifluoromethoxy)phenylmagnesium bromide Chemical Properties

Density 

0.975 g/mL at 25 °C

Flash point:

-30 °C

form 

liquid

InChI

1S/C7H4F3O.BrH.Mg/c8-7(9,10)11-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1

InChIKey

UFMHNMPAQCQXMW-UHFFFAOYSA-M

SMILES

FC(F)(F)Oc1ccc([Mg]Br)cc1

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-14-19-34-40-37

Safety Statements 

16-26-36/37/39-45

RIDADR 

UN 2924 3/PG 2

WGK Germany 

3

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Carc. 2
Eye Dam. 1
Flam. Liq. 2
Skin Corr. 1B
STOT SE 3

4-(Trifluoromethoxy)phenylmagnesium bromide Usage And Synthesis

Uses

Reactant for:

• Preparation of chromanol derivatives as novel class of CETP inhibitors for treatment of cardiovascular disease
• Pd-catalyzed cross coupling
• Preparation of indazole-pyridine derivatives as protein kinase B/Akt inhibitors with reduced hypotension, via Stille coupling, Mitsunobu reaction and copper-catalyzed aziridine ring-opening reaction

reaction suitability

reaction type: Grignard Reaction

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