Isobutylamine Chemical Properties

Melting point:

-85 °C (lit.)

Boiling point:

64-71 °C (lit.)

Density 

0.736 g/mL at 25 °C (lit.)

vapor pressure 

15.9kPa at 20℃

FEMA 

4239 | ISOBUTYLAMINE

refractive index 

n20/D 1.397(lit.)

Flash point:

15 °F

storage temp. 

Store below +30°C.

solubility 

1000g/l

form 

Liquid

pka

pK1:10.41(＋1) (25°C)

color 

Clear colorless to slightly yellow

PH

12.2 (100g/l, H2O, 20℃)

Odor

Strong ammoniacal.

explosive limit

2-9%(V)

Odor Type

fishy

Odor Threshold

0.0015ppm

Water Solubility 

soluble

Merck 

14,5132

JECFA Number

1583

BRN 

385626

Dielectric constant

4.4（Ambient）

LogP

-0.3 at 25℃

CAS DataBase Reference

78-81-9(CAS DataBase Reference)

NIST Chemistry Reference

1-Propanamine, 2-methyl-(78-81-9)

EPA Substance Registry System

Isobutylamine (78-81-9)

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-22-35

Safety Statements 

26-36/37/39-45

OEL

STEL: 5.0 ppm; 15.0 mg/m3

RIDADR 

UN 1214 3/PG 2

WGK Germany 

1

RTECS 

NP9900000

F 

10-23

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29211990

Hazardous Substances Data

78-81-9(Hazardous Substances Data)

Toxicity

LD50 (14 day) in male, female rats (mg/kg): 224.4, 231.8 orally (Cheever)

MSDS

• Language:English Provider:Isobutylamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Isobutylamine Usage And Synthesis

Chemical Properties

Clear colorless to slightly yellow liquid

Chemical Properties

Colorless to yellow liquid; fishy cheesy aroma.

Chemical Properties

Isobutylamine is a flammable liquid, miscible with water, alcohol, and ether.

Chemical Properties

Butyl amines are highly flammable, colorless liquids (n-turns yellow on standing) with ammoniacal or fishlike odors. n-isomer:

Uses

Isobutylamine is used as pharmaceutical intermediate.

Uses

Isobutylamine may be used in the synthesis of N-i-butyl-9(Z),12(Z),15(Z)-octadecatrienamide by reacting with trilinolenin. It can also react with tropolone to form a hydrogen-bonded complex, iso-butyl-ammonium 7-oxo-cyclo-hepta-1,3,5-trien-1-olate. Fullerene (C₆₀) can undergo oxyamination with isobutylamine to form polyamines.

Uses

Organic synthesis, insecticides.

Definition

ChEBI: An alkylamine having isobutyl as the alkyl group. It has been isolated from Sambucus nigra (Elderberry).

Production Methods

Isobutylamine is manufactured from isobutanol and ammonia or by the thermal decomposition of valine to isoleucine.

Aroma threshold values

High strength odor, fishy type; recommend smelling in a 0.10% solution or less.

General Description

A clear colorless liquid with a fishlike odor. Flash point 15°F. Less dense (6.1 lb / gal) than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

Isobutylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Flammable, dangerous fire risk. Strong irritant to skin and mucous membranes.

Health Hazard

Inhalation causes severe coughing and chest pain due to irritation of air passages; can cause lung edema. Compound is sympathomimetic and is also a cardiac depressant and convulsant; ingestion causes nausea and profuse salivation. Contact with eyes causes severe irritation and edema of the cornea. Contact with skin causes severe irritation.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Potential Exposure

Alert: (n-isomer): Possible risk of forming tumors, suspected of causing genetic defects, suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (sec-isomer): Drug. n-Butylamine is used in pharmaceuticals; dyestuffs, rubber, chemicals, emulsifying agents; photography, desizing agents for textiles; pesticides, and synthetic agents. sec-Butylamine is used as a fungistate. tert-Butylamine is used as a chemical intermediate in the production of tert-Butylaminoethyl methacrylate (a lube oil additive); as an intermediate in the production of rubber and in rust preventatives and emulsion deterrents in petroleum products. It is used in the manufacture of several drugs

Shipping

UN1125 n-Butylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material. UN2014 Isobutylamine, Hazard Class: 3; Labels: 3—Flammable liquid, 8—Corrosive material

Incompatibilities

May form explosive mixture with air. May accumulate static electrical charges, and may causeignition of its vapors. n-Butylamine is a weak base; reacts with strong oxidizers and acids, causing fire and explosion hazard. Incompatible with organic anhydrides; isocyanates, vinyl acetate; acrylates, substituted allyls; alkylene oxides; epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresols, caprolactum solution. Attacks some metals in presence of moisture. The tert-isomer will attack some forms of plastics

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner andscrubber. All federal, state, and local environmental regulations must be observed.

Isobutylamine(78-81-9)Related Product Information

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