6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Chemical Properties

Melting point:

252-253 °C (decomp)(Solv: ethanol (64-17-5))

Boiling point:

282 ºC

Density 

1.468

Flash point:

124 ºC

storage temp. 

2-8°C

pka

9.33±0.70(Predicted)

InChI

InChI=1S/C10H5F4NO/c11-5-1-2-8-6(3-5)7(10(12,13)14)4-9(16)15-8/h1-4H,(H,15,16)

InChIKey

WUFRBOSKPZUGIS-UHFFFAOYSA-N

SMILES

N1C2=C(C=C(F)C=C2)C(C(F)(F)F)=CC1=O

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

29334900

6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Usage And Synthesis

Chemical Properties

White solid

Description

As a quinoline derivative, 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is substituted with trifluoromethyl, hydroxyl, and fluoride groups. In particular, 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline can exist in a tautomeric form, known as quinolone, where the hydroxy group becomes a ketone and the imine changes to an amine. This compound is a precursor for synthesizing thioquinolines, which are used to develop non-cytotoxic, potent and selective antitubercular agents. The thiolation reaction is carried out using phosphorus pentasulfide in pyridine.

6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone(328956-08-7)Related Product Information

• Trifluoromethanesulfonic acid
• 3-Aminobenzotrifluoride
• 3-(Trifluoromethyl)benzaldehyde
• (Trifluoromethyl)trimethylsilane
• 2-(Trifluoromethyl)benzoic acid
• 2-Methylbenzotrifluoride
• 2-(Trifluoromethyl)benzyl chloride
• 6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97%
• 2-Hydroxy-4-(trifluoromethyl)quinoline
• Fluorine
• 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone