Amorolfine Chemical Properties

Boiling point:

407.1±33.0 °C(Predicted)

Density 

0.924±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator, under inert atmosphere

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

pka

7.33±0.10(Predicted)

color 

Colourless

Amorolfine Usage And Synthesis

Uses

Amorolfine is available for topical use in 0.25% cream and 5% nail lacquer formulation for the treatment of onychomycosis in European countries and Japan. However, amorolfine is not approved in the USA for such indications. The major advantage of this new antimycotic drug presumably lies in its potential for use as 5% nail lacquer in the treatment of onychomycosis caused by dermatophytes and Candida spp.

Side effects

Topical application of amorolfine (5% nail lacquer and 0.25% cream) is generally well tolerated, with up to 5% of patients reporting minor symptoms. In patients using the nail lacquer, these events included burning, itching, redness, and local pain, which were toleratable and confined to the application site. Adverse effects of scaling, weeping, blistering, and edema have also been described for the cream formulation.

Uses

Antimycotic.

Uses

Amorolfine is a novel antifungal agent used in the treatment of cutaneous fungal disease.

brand name

Loceryl (Hoffmann-LaRoche).

Amorolfine(67467-83-8)Related Product Information

• Dimethomorph
• Itraconazole
• Ciclopirox ethanolamine
• Ciclopirox
• Terbinafine hydrochloride
• Amorolfine Hydrochloride
• Chlorodimethylphenylsilane
• Moroxydine
• Moroxydine hydrochloride
• PHENYL VALERATE
• Tridemorph
• Phenylacetic acid
• Amorolfine
• Amorolfine
• flumorph