17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one Chemical Properties

Melting point:

169°

alpha 

D20 +63° (c = 0.5 in alc)

Boiling point:

376.15°C (rough estimate)

Density 

1.1129 (rough estimate)

refractive index 

1.4800 (estimate)

pka

12.76±0.40(Predicted)

color 

Pale-yellow needles from diisopropyl ether

17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one Usage And Synthesis

Uses

Norgestrienone is a progestin receptor agonist. Norgestrienone is commonly used as a progesterone compound in birth control pills and can be combined with ethinylestradiol. Norgestrienone is a click chemical. It contains Alkyne groups and can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Azide groups. Norgestrienone can be used in the study of hereditary angioneurotic edema[1][2].

Definition

ChEBI: Norgestrienone is a steroid. It has a role as an estrogen.

Safety Profile

Human female reproductiveeffects by implant and intravaginal routes: changes inmenstrual cycle and fertility. When heated todecomposition it emits acrid smoke and irritating fumes

References

[1] S Diaz, et al. Diaz S, Pavez M, Quinteros E, Diaz J, Robertson DN, Croxatto HB. Clinical trial with subdermal implants containing norgestrienone. Contraception. 1978 Oct;18(4):429-40. DOI:10.1016/0010-7824(78)90027-6
[2] Wu X, et al. Gestrinone combined with ultrasound-guided aspiration and ethanol injection for treatment of chocolate cyst of ovary. J Obstet Gynaecol Res. 2015 May;41(5):712-6. DOI:10.1111/jog.12612

17-Hydroxy-19-nor-17alpha-pregna-4,9,11-trien-20-yn-3-one(848-21-5)Related Product Information

• (-)-NORGESTREL 98
• CHLOROPHOSPHONAZO III
• 17alpha-Ethynyl-19-nortestosterone 17-heptanoate
• Quinocetone
• Norethindrone
• Gestodene
• Norgestrel
• Gestrinone
• 3,6-DIMETHYL-1-HEPTYN-3-OL
• 3,4-DIMETHYL-1-PENTYN-3-OL
• 3,5-DIMETHYL-1-HEXYN-3-OL
• CYCLOPENTYLACETYLENE
• 1-ETHYNYLCYCLOPENTANOL
• 3-METHYL-1-DODECYN-3-OL
• 3,4,4-TRIMETHYL-1-PENTYN-3-OL
• 3-CYCLOPENTYL-2-METHYL-1-PROPENE
• Methyltrienolone
• 7-OCTEN-2-OL, 2-METHYL-6-METHYLENE