(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride Basic information
- Product Name:
- (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
- Synonyms:
-
- (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride
- (+)-DehydroabiethylaMine Hydrochloride
- 13-Isopropyl-podocarpa-8,11,13-trien-15-aMine Hydrochloride
- ((1S,4aS)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methanamine hydrochloride
- Dehydroabietylamine Hydrochloride
- DehydroabiethylaMine Hydrochloride
- [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine
- CAS:
- 16496-99-4
- MF:
- C20H32ClN
- MW:
- 321.93
- Product Categories:
-
- Antifungal
- Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File:
- 16496-99-4.mol
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride Chemical Properties
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 40 mg/ml) or in Water (up to 9 mg/ml).
- form
- solid
- color
- Off-white or beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride Usage And Synthesis
Description
Leelamine HCl (16496-99-4) is a lysosomotropic, intracellular cholesterol transport inhibitor with potential chemotherapeutic activity. Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux.1?Induces apoptosis in breast cancer2, melanoma3?and prostate cancer cells4. A selective inducer of cytochrome P450 2B.5?Inhibits pyruvate dehydrogenase kinase (PDK), IC50=9.5 μM.6
Uses
Dehydroabiethylamine is a primary amine with high molecular weight; shows a strong antibiotic effect with a broad spectrum of activity against Staphylococcus p.a. (sic), Escherichia coli, Mycobacterium tuberculosis, and Candida albicans.
Uses
Resolving agent for carboxylic acids
IC 50
CB1
References
[1] OMER F KUZU. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.[J]. Molecular Cancer Therapeutics, 2014, 13 7: 1690-1703. DOI:10.1158/1535-7163.mct-13-0868
[2] ANURADHA SEHRAWAT. Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation.[J]. Molecular Carcinogenesis, 2017, 56 2: 337-348. DOI:10.1002/mc.22497
[3] YU-CHI CHEN. Targeting cholesterol transport in circulating melanoma cells to inhibit metastasis[J]. Pigment Cell & Melanoma Research, 2017, 30 6: 541-552. DOI:10.1111/pcmr.12614
[4] KRISHNA B SINGH Shivendra V S Xinhua Ji. Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer.[J]. Molecular Cancer Therapeutics, 2018, 17 10: 2079-2090. DOI:10.1158/1535-7163.mct-18-0117
[5] JUHEE SIM. Selective induction of hepatic cytochrome P450 2B activity by leelamine in vivo, as a potent novel inducer[J]. Archives of Pharmacal Research, 2014, 38 5: 725-733. DOI:10.1007/s12272-014-0443-0
[6] THOMAS D. AICHER ∗. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK)[J]. Bioorganic & Medicinal Chemistry Letters, 1999, 9 15: Pages 2223-2228. DOI:10.1016/s0960-894x(99)00380-7
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