3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE
3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE Basic information
- Product Name:
- 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE
- Synonyms:
-
- GW3965
- GW 3965 HYDROCHLORIDE
- 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE
- 3-[3-[[[2-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]METHYL](2,2-DIPHENYLETHYL)AMINO]PROPOXY]BENZENEACETIC ACID HYDROCHLORIDE
- 3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-diphenylethyl)aMino]propvloxy]phenylacetic acid hydrochloride
- 2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)-amino)propoxy)phenyl)acetic a
- 2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)-amino)propoxy)phenyl)acetic acid
- Benzeneacetic acid,3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-
- CAS:
- 405911-09-3
- MF:
- C33H31ClF3NO3
- MW:
- 582.05
- Product Categories:
-
- Inhibitor
- Mol File:
- 405911-09-3.mol
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3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE Chemical Properties
- Melting point:
- 174-179°C
- Boiling point:
- 672.4±55.0 °C(Predicted)
- Density
- 1.261±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.18±0.10(Predicted)
- color
- White to Off-White
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3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE Usage And Synthesis
Uses
GW3965 can be used in biological study of effect of liver X receptor agonists, T0901317 and GW3965 treatment on cholesterol efflux and apoptosis in human CAL-1 and GEN2.2 blastic plasmacytoid dendritic cell neoplasm cells.
Definition
ChEBI: GW 3965 is a diarylmethane.
Biological Activity
Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXR α and hLXR β (EC 50 values are 190 and 30 nM respectively). Up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.
target
LXRα
3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDESupplier
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