4-Methoxyphenylhydrazine hydrochloride Chemical Properties

Melting point:

160-162 °C (dec.)(lit.)

storage temp. 

Keep Cold

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Powder, Crystals and/or Chunks

color 

Slightly pink to gray to purple

Water Solubility 

soluble

BRN 

3566583

Stability:

Light Sensitive

InChI

InChI=1S/C7H10N2O.ClH/c1-10-7-4-2-6(9-8)3-5-7;/h2-5,9H,8H2,1H3;1H

InChIKey

FQHCPFMTXFJZJS-UHFFFAOYSA-N

SMILES

C1(NN)=CC=C(OC)C=C1.Cl

CAS DataBase Reference

19501-58-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

36/37-36-26

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Irritant/Harmful

HazardClass 

IRRITANT, KEEP COLD

PackingGroup 

III

HS Code 

29280090

MSDS

• Language:English Provider:1-(4-Methoxyphenyl)hydrazine hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Methoxyphenylhydrazine hydrochloride Usage And Synthesis

Description

4-Methoxyphenylhydrazine hydrochloride is a kind of midbody that is mainly used for producing phenylhydrazine, and can also be used to make other Chemicals. The reparation technology of 4-Methoxyphenylhydrazine hydrochloride comprises aniline diazonium and benzene diazonium chloride diazo benzene chloride two-step process.

Chemical Properties

slightly pink to greyish-purple powder

Uses

4-Methoxyphenylhydrazine hydrochloride was used in the preparation of 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole.

Synthesis

4-Methoxyphenylhydrazine hydrochloride Preparation Process: Take hydrochloric acid and sodium nitrite and add them sequentially to aniline, where the molar ratio of aniline to hydrochloric acid to sodium nitrite is 1:2.3 to 3.2:1 to 1.1, and sodium nitrite is added at 0 to 5°C. The reaction temperature is 0 to 22°C, and the reaction time is 30 to 90 minutes. Then add ammonium sulfite and hydrochloric acid according to a molar ratio to aniline of 1:2 to 3.5:2.5 to 3.0. After reduction, hydrolysis, and acidification, the product can be obtained by filtration or centrifugation.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3322 - 3336
[2] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 1, p. 1 - 11
[3] Russian Chemical Bulletin, 2005, vol. 54, # 10, p. 2417 - 2424
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[5] Journal of Organic Chemistry, 2011, vol. 76, # 13, p. 5295 - 5308

4-Methoxyphenylhydrazine hydrochloride(19501-58-7)Related Product Information

• 1-Acetyl-2-phenylhydrazine
• (Trifluoromethoxy)benzene
• Phenylhydrazine hydrochloride
• 2-Ethylphenylhydrazine hydrochloride
• Anisole
• Topotecan hydrochloride
• p-Anisidine
• 4-Hydrazinylbenzoic acid
• p-Anisaldehyde
• HYDRAZINE
• 1,4-Butane sultone
• Glutacondianil hydrochloride
• 1,1,2-Trimethyl-1H-benz[e]indole
• 4-Benzyloxyphenylhydrazine hydrochloride
• 4-(Trifluoromethoxy)phenylhydrazine hydrochloride
• 3-Methoxyphenylhydrazine hydrochloride, 98+%,3-METHOXYPHENYLHYDRAZINE HYDROCHLORIDE
• 3,4-DIMETHOXYPHENYLHYDRAZINE HYDROCHLORIDE
• 5-amino-2-(2,6-dichloro-4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one