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Hygromycin B

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Hygromycin B Basic information

Product Name:
Hygromycin B
Synonyms:
  • antihelmycin
  • hydromycinb
  • hygromix2.4
  • hygromix-8
  • hygrovetine
  • Hygromycin Solution
  • Hygromix
  • 5-O-(2,3-O-(6-Amino-6-desoxyheptapyranosyliden)-beta-D-talopyranosyl)-desoxy-N'-methyl-D-streptamin
CAS:
31282-04-9
MF:
C20H37N3O13
MW:
527.52
EINECS:
250-545-5
Product Categories:
  • antibiotic
  • Inhibitors
Mol File:
31282-04-9.mol
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Hygromycin B Chemical Properties

Melting point:
160-180°C
alpha 
D20 +20.2° (c = 1 in water)
Boiling point:
608.13°C (rough estimate)
Density 
1.4252 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.
pka
7.1, 8.8(at 25℃)
form 
powder
color 
faintly brown to brown
PH
pH (25g/l, 25℃ ) : 9.5~12.5
Water Solubility 
Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents.
Merck 
14,4852
BRN 
6755837
EPA Substance Registry System
Hygromycin B (31282-04-9)
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Safety Information

Hazard Codes 
T+,Xn,T
Risk Statements 
26/27/28-41-42/43-40-36-23/24/25
Safety Statements 
23-26-28-36/37/39-45-22-36-36/37
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
WK2130000
19
HazardClass 
6.1
PackingGroup 
I
HS Code 
29419059
Toxicity
mmo-esc 250 mg/L AACHAX 18,798,80
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Hygromycin B Usage And Synthesis

Chemical Properties

White to off-white lyophilized powder

Uses

antibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg

Uses

Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome

Uses

Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib osome

Uses

Hygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2.

General Description

Amorphous solid or tan powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Weakly basic.

Fire Hazard

Flash point data for Hygromycin B are not available; however Hygromycin B is probably combustible.

Safety Profile

Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox

Hygromycin BSupplier

Hunan Hui Bai Shi Biotechnology Co., Ltd. Gold
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