1-ETHYL-1,2,4-TRIAZOLE Chemical Properties

Boiling point:

65-68 °C(Press: 12 Torr)

Density 

1.11±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.25±0.10(Predicted)

1-ETHYL-1,2,4-TRIAZOLE Usage And Synthesis

Chemical Properties

Colorless and transparent to light yellow liquid

Synthesis

Scheme 3. Synthesis of 1-ethyl-1H-1,2,4-triazole (26a). Scheme 6. Preparation of intermediate 26a. Step 1. Synthesis of 1-ethyl-1H-1,2,4-triazole (26a): ethyl iodide (7 mL, 86.9 mmol) was added to an anhydrous THF (50 mL) solution of 1,2,4-triazole (5 g, 72.4 mmol) under ice bath conditions. Subsequently, DBU (10.8 mL, 72.4 mmol) was added slowly and dropwise over 10-20 min to the cloudy reaction system. The reaction mixture was gradually warmed to room temperature and stirred overnight. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to give 10 g of crude product as a yellow liquid. The crude product was purified by Kugelrohr distillation (~300 mTorr, 35-40 °C) to give 4.9 g (70% yield) of the target product 26a as a clear liquid.

References

[1] Patent: WO2011/5520, 2011, A1. Location in patent: Page/Page column 31-32
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 31, p. 4331 - 4337
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 23, p. 7089 - 7092
[4] Patent: WO2010/67125, 2010, A1. Location in patent: Page/Page column 85

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