MMP-2/MMP-9 INHIBITOR IV Chemical Properties

Melting point:

92-96°C

Boiling point:

501.4±46.0 °C(Predicted)

Density 

1.329±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: >20mg/mL

form 

powder

color 

white to off-white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

HS Code 

29349990

MMP-2/MMP-9 INHIBITOR IV Usage And Synthesis

Uses

SB 3CT is a selective and potent gelatinase inhibitor which may be used for the treatment of brain metastasis.

Uses

SB?3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation.

Definition

ChEBI: 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane is an aromatic ether.

Biochem/physiol Actions

SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM).

storage

Store at -20°C

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