LIMAPROST
LIMAPROST Basic information
- Product Name:
- LIMAPROST
- Synonyms:
-
- (2e,11-alpha,13e,15s,17s)-11,15-dihydroxy-17,20-dimethyl-9-oxoprost-2,13-die
- ,13e,15s,17s)-
- 11α,15s-dihydroxy-17s,20-dimethyl-9-oxo-prosta-2e,13e-dien-1-oic acid
- 17S,20-Dimethyl-trans-D2-PGE1
- 2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-, (2E)- (9CI)
- Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11a,13E,15S,17S)-
- 17α,20-dimethyl-δ2-PGE1, 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid
- (2E)-7-[(1R)-2β-[(1E,3S,5S)-3-Hydroxy-5-methyl-1-nonenyl]-3α-hydroxy-5-oxocyclopentan-1α-yl]-2-heptenoic acid
- CAS:
- 74397-12-9
- MF:
- C22H36O5
- MW:
- 380.52
- Product Categories:
-
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 74397-12-9.mol
LIMAPROST Chemical Properties
- Melting point:
- 97-100°
- Boiling point:
- 550.6±50.0 °C(Predicted)
- Density
- 1.118
- storage temp.
- -20°C
- solubility
- DMF: soluble
- form
- crystalline
- pka
- 4.78±0.10(Predicted)
- color
- White to off-white
- InChIKey
- OJZYRQPMEIEQFC-UAWLTFRCSA-N
- SMILES
- C(O)(=O)/C=C/CCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C[C@@H](C)CCCC
Safety Information
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- UK8362500
MSDS
- Language:English Provider:SigmaAldrich
LIMAPROST Usage And Synthesis
Chemical Properties
White crystals, melting point 97-100℃.
Uses
Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.
Definition
ChEBI: Limaprost is a long-chain fatty acid.
Biochem/physiol Actions
Limaprost exhibits cytoprotective, vasodilatory, and antiplatelet activity. Limaprost has the potential to treat lumbar spinal canal stenosis (LSCS) and several ischaemic symptoms of thromboangiitis obliterans (TAO).
in vivo
Limaprost (OP1206) given orally at more than 100 μg/kg relieves Argipressin-induced ST depression of rat electrocardiogram (ECG)[1].
Intra-coronary injection of Limaprost (OP1206; 1-100 ng/kg) in dogs results in a remarkable increase of coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption and redox potential[1].
Resistance in both large and small vessels of dog coronary artery is decreased by intravenous injection of Limaprost (OP1206; 1-3 mg/kg)[1].
Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost (OP1206) at the same doses or doses less than those relieving Argipressin-induced ST depression of ECG[1].
LIMAPROST Preparation Products And Raw materials
Raw materials
LIMAPROSTSupplier
- Tel
- 027-83778876 13667159345
- 13667159345@163.com
- Tel
- 13012344321
- 3995296515@qq.com
- Tel
- sales@boylechem.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 021-50790412
- info@chemvon.com