Basic information Indications and Usage Mechanisms of Action Adverse reactions Toxicity Level Acute Toxicity Flammability Characteristics Handling Extinguishers Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Amino Acids and proteins >  L(+)-Arginine

L(+)-Arginine

L-arginine is a coded amino acid in the synthesis of protein, belonging to one of the eight essential amino acids in the human body. It is needed it to exercise a variety of functions in the body. For example, it stimulates the release of specific chemicals, such as insulin and human growth hormones. The amino acid also helps to remove ammonia from the body and promote wound healing. The body producing sarcosine also needs it. In the decomposition of L-arginine will produce nitric oxide, and it could expand vascular disease and increase blood flow. Under normal circumstances, the body itself can produce enough L-arginine. But in the absence, you can eat arginine-rich foods to add arginine.

Basic information Indications and Usage Mechanisms of Action Adverse reactions Toxicity Level Acute Toxicity Flammability Characteristics Handling Extinguishers Safety Supplier Related

L(+)-Arginine Basic information

Product Name:
L(+)-Arginine
Synonyms:
  • ABL2 (38-end), active, His tagged human
  • FLJ41441
  • ANTI-ABL2 antibody produced in mouse
  • FLJ22224
  • FLJ31718
  • Abelson murine leukemia viral oncogene homolog 2
  • Abelson tyrosine-protein kinase 2
  • ABL2
CAS:
74-79-3
MF:
C6H14N4O2
MW:
174.2
EINECS:
200-811-1
Product Categories:
  • Amino Acids
  • pharmacetical
  • chiral
  • Arginine [Arg, R]
  • Amino Acids
  • Amino Acids and Derivatives
  • for Resolution of Acids
  • Optical Resolution
  • alpha-Amino Acids
  • Biochemistry
  • Synthetic Organic Chemistry
  • L-Amino Acids
  • Nitric Oxide
  • amino
Mol File:
74-79-3.mol
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L(+)-Arginine Chemical Properties

Melting point:
222 °C (dec.) (lit.)
alpha 
27.1 º (c=8, 6N HCl)
Boiling point:
305.18°C (rough estimate)
Density 
1.2297 (rough estimate)
FEMA 
3819 | L-ARGININE
refractive index 
27 ° (C=8, 6mol/L HCl)
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
pka
1.82, 8.99, 12.5(at 25℃)
color 
white
PH
10.5-12.0 (25℃, 0.5M in H2O)
PH Range
10.5 - 12
optical activity
[α]20/D +27°, c = 8 in 6 M HCl
Water Solubility 
148.7 g/L (20 ºC)
λmax
λ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1
Sensitive 
Air Sensitive
JECFA Number
1438
Merck 
14,780
BRN 
1725413
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
ODKSFYDXXFIFQN-BYPYZUCNSA-N
CAS DataBase Reference
74-79-3(CAS DataBase Reference)
NIST Chemistry Reference
L-Arginine(74-79-3)
EPA Substance Registry System
L-Arginine (74-79-3)
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Safety Information

Hazard Codes 
Xn,T
Risk Statements 
36-36/37/38-20/21/22-61
Safety Statements 
24/25-36-26-45-53-39
WGK Germany 
3
RTECS 
CF1934200
10-23
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29252000
Hazardous Substances Data
74-79-3(Hazardous Substances Data)
Toxicity
cyt-grh-par 100 mmol/L IJEBA6 24,460,86

MSDS

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L(+)-Arginine Usage And Synthesis

Indications and Usage

Odorless, slightly bitter. Easily soluble in water (solubility in 0℃ water is 83g/L, solubility in 50℃ water is 400g/L), very slightly soluble in ethanol, insoluble in ether; pI6.0; loses its 2-molecule water crystal when heated to 105℃, darkens in color at 230℃, disintegrates at 244℃; its aqueous solution has maximum absorption at 205nm (1gε3.28).
L-Arginine is an encoding amino acid in protein synthesis and is one of the 8 essential amino acids in the human body. The body needs it for many different functions. Taking L-Arginine supplements can treat certain diseases such as congestive heart failure and cystitis. L-Arginine can also act as seasoning for nutrient supplements and food additives. L-Arginine can undergo a heat reaction with sugar (amino-carbonyl reaction) to obtain a unique fragrance, GB 2760-2001, an approved food spice. As an amino acid drug, L-Arginine can be used as pharmaceutical raw material and is an important ingredient in amino acid infusions and integrated amino acid preparations. It is also a crucial amino acid in maintaining infant growth and maturation.

Mechanisms of Action

L-Arginine can stimulate the human body to release certain chemicals such as insulin and human growth hormone. It can also clear ammonia in the body and promote the healing of wounds. The human body also needs it to produce sarcosine. Decomposing L-Arginine produces nitric oxide, which can expand blood vessels and increase blood flow. L-Arginine is an intermediate metabolite in the orthinine cycle and promotes the conversion of ammonia to urea, thus lowering the blood concentration of ammonia. L-Arginine is also an important part of sperm protein and can promote spermatogenesis and provide energy for sperm movement. Additionally, intravenous arginine can stimulate the pituitary to release growth hormone and can be used to test pituitary functions.

Adverse reactions

Abdominal pain, diarrhea, gout and bloating. There may also be increased severity in herpes breakouts and increased effects of antihypertensive drugs, resulting in a lower blood pressure than expected, which may cause hypertensive patients to experience dizziness and fainting.

Toxicity Level

Moderate

Acute Toxicity

Reference data: abdominal cavity – large rat LD50: 3793 mg/kg.

Flammability Characteristics

Flammable. Burning produces toxic nitrogen oxide smoke.

Handling

Store in ventilated, cool and dry area.

Extinguishers

Dry powder, foam, sand, carbon dioxide, water mist.

Chemical Properties

Arginine is a diaminomonocarboxylic acid. The nonessential amino acid, arginine, is a urea cycle amino acid and a precursor for the neurotransmitter nitric oxide, which plays a role in the regulation of the brain’s system of dilation and constriction of small blood vessels. It is strongly alkaline and its water solutions absorb carbon dioxide from the air (FCC, 1996). Functionality in foods includes, but is not limited to, nutrient and dietary supplement

Chemical Properties

White crystalline powder

Occurrence

Reported present in cheese, chocolate, eggs, meat, nuts and other products.

Uses

L-Arginine is used for heart and blood vessel conditions which includes congestive heart failure (CHF), chest pain, high blood pressure and coronary artery disease. It plays a vital role in the treatment of cardiovascular disease due to it being antiatherogenic, anti-ischemic, antiplatelet and antithrombotic. It acts as a growth stimulant and is involved in the treatment of erectile dysfunction in men. It is an important ingredient of tooth paste which provides effective relief for sensitive teeth.

Uses

Amino acid; nutrient.

Definition

ChEBI: An L-alpha-amino acid that is the L-isomer of arginine.

Aroma threshold values

Detection at 100%, faint.

Taste threshold values

Taste characteristics at 1000 ppm: hint of sourness.

General Description

L-Arginine is an amino acid that plays a key role in many physiological processes such as tissue repair and reproduction. It is a key precursor for synthesizing nitric oxide in mammals. Due to these factors, the dietary supplementation with L-arginine may show a range of health benefits.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.

Chemical Synthesis

Enzymatically, arginine is formed in two reactions from citrulline. The first reaction (citrulline + succinate) is catalyzed by the enzyme arginosuccinate synthetase. It is ATP dependent and with the formation of a new C–N bond in the gaunidino group of arginosuccinate, water is removed and ATP is hydrolyzed. The second reaction is catalyzed by arginine synthetase and involves the scission of arginosuccinate with the formation of arginine and fumaric acid.

Purification Methods

S-Arginine crystallises from H2O as the dihydrate and as plates from EtOH. It also crystallises from 66% EtOH. Its solubility in H2O is 15% at 21o. Its isoelectric point is at pH 10.76. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1841 1961, Beilstein 4 IV 817.]

L(+)-ArginineSupplier

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Product Name:L-Arginine(Base)
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Products Intro
Product Name:L(+)-Arginine
CAS:74-79-3
Purity:99.9% Package:500000kg Remarks:450000kg