4,4'-SULFONYLBIS(2-METHYLPHENOL) Chemical Properties

Melting point:

273-276 °C(lit.)

Boiling point:

518.8±50.0 °C(Predicted)

Density 

1.343±0.06 g/cm3(Predicted)

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

7.25±0.20(Predicted)

color 

Pale Orange to Pale Red

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

4,4'-SULFONYLBIS(2-METHYLPHENOL) Usage And Synthesis

Uses

Topoisomerase IIα-IN-9 (NSC85582) is a bisphenol compound that has a moderate inhibitory effect on DNA topoisomerase Topoisomerase II (IC50: 571 μM). Topoisomerase IIα-IN-9 also exhibits a certain cell growth inhibitory effect, with IC50s of 117 μM and 218 μM for K562 and CHO, respectively[1].

References

[1] A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase II Inhibitors

4,4'-SULFONYLBIS(2-METHYLPHENOL)(16346-97-7)Related Product Information

• BIS(4-HYDROXY-3,5-DIMETHYLPHENYL) SULFONE
• 4,4'-Thiobis-phenol
• Bis(4-hydroxyphenyl) Sulfone
• 4-METHYLTHIO-ORTHO-CRESOL
• 4,4'-SULFONYLBIS(2-METHYLPHENOL)
• BIS(4-HYDROXY-3-METHYLPHENYL) SULFIDE
• 3-METHYLDIPHENYLSULFIDE
• 3,3'-Sulfonylbis(6-methylphenol)
• 3,3'-Sulfonylbis(5-methylphenol)
• 4,4'-Sulfonylbis(3-methylphenol)
• 2,2'-Sulfonylbis(6-methylphenol)
• 2,2'-Sulfonylbis(5-methylphenol)
• 3,3'-Sulfonylbis(4-methylphenol)
• 3,3'-Sulfonylbis(2-methylphenol)
• 2,2'-Sulfonylbis(4-methylphenol)
• 2,2'-Sulfonylbis(3-methylphenol)
• 4-((4-[(3-CHLORO-2,2-DIMETHYLPROPANOYL)OXY]-3,5-DIMETHYLPHENYL)SULFONYL)-2,6-DIMETHYLPHENYL 3-CHLORO-2,2-DIMETHYLPROPANOATE
• 4-((3,5-DIMETHYL-4-[(2,3,3-TRICHLOROACRYLOYL)OXY]PHENYL)SULFONYL)-2,6-DIMETHYLPHENYL 2,3,3-TRICHLOROACRYLATE