(S)-1-Boc-2-(Hydroxymethyl)piperazine Chemical Properties

Boiling point:

324℃

Density 

1.085

Flash point:

150℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

14.97±0.10(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-6-8(12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m0/s1

InChIKey

BCPPNDHZUPIXJM-QMMMGPOBSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCNC[C@H]1CO

Safety Information

HS Code 

2933599590

(S)-1-Boc-2-(Hydroxymethyl)piperazine Usage And Synthesis

Uses

(S)-1-N-Boc-2-hydroxymethyl piperazine is a heterocyclic compound and can be used as an intermediate in pharmaceutical synthesis.

Uses

(S)-1-Boc-2-hydroxymethyl-piperazine is a heterocyclic building block used in synthetic chemistry.

Reactions

(S)-1-Boc-2-(Hydroxymethyl)piperazine reacts with 1,2-difluoro-4-nitrobenzene to synthesize tert-butyl (S)-4-(2-fluoro-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate. This compound serves as a crucial intermediate in the preparation of the Wee-1 kinase activity inhibitor.

Synthesis

To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL), 10 % Pd/C (150 mg) was added. The mixture was stirred at room temperature for 3 hours under H2. Afterwards, the solid was removed by filtration and the filtrate was concentrated to yield (S)-1-Boc-2-(Hydroxymethyl)piperazine (850 mg, 3.93 mmol, 91.82 percent) as a white solid.

References

[1] Patent: US2018/127370, 2018, A1. Location in patent: Paragraph 1006; 1004

(S)-1-Boc-2-(Hydroxymethyl)piperazine(1030377-21-9)Related Product Information

• (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine
• tert-butyl (S)-2-(aminomethyl)-4,4-dimethylpyrrolidine-1-carboxylate
• (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester
• (R)-tert-Butyl 3-(methoxymethyl)piperazine-1-carboxylate
• (R)-1-N-Boc-2-(hydroxymethyl)piperazine
• (R)-4-benzyl-2-hydroxymethylpiperazine
• (S)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine
• (S)-4-benzyl-2-hydroxymethylpiperazine
• (S)-tert-butyl 2-(MethoxyMethyl)piperazine-1-carboxylate
• (S)-1-N-BOC-2-METHOXYMETHYLPIPERAZINE
• (S)-N-Boc-2-Hydroxymethylmorpholine
• (S)-N-Boc-2-aminomethylmorpholine
• tert-butyl (2R)-2-(MethoxyMethyl)piperazine-1-carboxylate
• tert-butyl (S)-2-(aminomethyl)-5-bromoindoline-1-carboxylate
• tert-butyl (S)-2-(aminomethyl)-4,4-difluoropiperidine-1-carboxylate
• (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
• (S)-1-N-BOC-4-N-FMOC-PIPERAZINE-2-CARBOXYLIC ACID
• (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid