Iopromide Chemical Properties

Melting point:

broad (160?C transition)

Boiling point:

840.9±65.0 °C(Predicted)

Density 

2.173±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

Freely soluble in water and in dimethyl sulfoxide, practically insoluble in ethanol (96 per cent) and in acetone.

form 

Solid

pka

10.62±0.70(Predicted)

color 

White to off-white

Stability:

Hygroscopic

InChI

InChI=1S/C18H24I3N3O8/c1-24(4-9(28)6-26)18(31)12-13(19)11(17(30)22-3-8(27)5-25)14(20)16(15(12)21)23-10(29)7-32-2/h8-9,25-28H,3-7H2,1-2H3,(H,22,30)(H,23,29)

InChIKey

DGAIEPBNLOQYER-UHFFFAOYSA-N

SMILES

C1(C(N(CC(O)CO)C)=O)=C(I)C(NC(COC)=O)=C(I)C(C(NCC(O)CO)=O)=C1I

CAS DataBase Reference

73334-07-3(CAS DataBase Reference)

EPA Substance Registry System

1,3-Benzenedicarboxamide, N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N1-methyl- (73334-07-3)

Safety Information

Hazard Codes 

N

Risk Statements 

50/53

Safety Statements 

60-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

RTECS 

CZ2230000

HazardClass 

9

HS Code 

2924296000

Toxicity

LD50 in mice, rats (g iodine/kg body weight): 16.5, 11.4 i.v. (Muetzel)

Iopromide Usage And Synthesis

Description

Iopromide is a non-ionic, water-soluble X-ray contrast agent for intravascular administration. Iopromide can cause acute kidney injury and is used in animal models of contrast-induced nephropathy.

Chemical Properties

White Solid

Uses

Contrast molecule

Uses

Labelled Iopromide. Nonionic, injectable radio-contrast medium. Diagnostic aid (radiopaque medium).

Definition

ChEBI: A dicarboxylic acid diamide that consists of N-methylisophthalamide bearing three iodo substituents at positions 2, 4 and 6, a methoxyacetyl substituent at position 5 and two 2,3-dihydroxypropyl groups attached to the amide nitrogens. A ater soluble x-ray contrast agent for intravascular administration.

brand name

Ultravist (Berlex).

General Description

Iopromide is a low-osmolar,nonionic monomer with 48% bound iodine content. It is indicatedfor use in angiography, excretory urography, andnumerous CT procedures.

References

[1] YOUNG-HWAN AHN. The potential utility of iodinated contrast media (ICM) skin testing in patients with ICM hypersensitivity.[J]. Journal of Korean Medical Science, 2015, 30 3: 245-251. DOI: 10.3346/jkms.2015.30.3.245
[2] JIN-YONG PARK. A new micro-computed tomography-based high-resolution blood-brain barrier imaging technique to study ischemic stroke.[J]. Stroke, 2014, 45 8: 2480-2484. DOI: 10.1161/strokeaha.114.006297
[3] KAMAL HASSAN  Hassan F. Is hypoalbuminemia a prognostic risk factor for contrast-induced nephropathy in peritoneal dialysis patients?[J]. Therapeutics and Clinical Risk Management, 2014, 10: 787-795. DOI: 10.2147/tcrm.s70665
[4] NA WANG. Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying Mechanism.[J]. Medical Science Monitor?: International Medical Journal of Experimental and Clinical Research, 2015: 2886-2892. DOI: 10.12659/msm.895543

Iopromide(73334-07-3)Related Product Information

• Iohexol
• Ioversol
• N1,N3-Bis(1,3-dihydroxypropan-2-yl)-5-(2-hydroxypropanamido)-2,4,6-triiodoisophthalamide
• Formamide
• Iodine
• Iopromide
• 3-(N-BENZYL-N-METHYLAMINO)-1,2-PROPANEDIOL
• 5-Amino-N,N'-bis(2,3-dihydroxypropyl)isophthalamide
• 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
• 5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
• 3,5-DIMETHYL-4-IODOANILINE
• 3-AMINOMETHYL-N,N-DIMETHYL-BENZAMIDE
• 3-DIMETHYLAMINOMETHYL-BENZYLAMINE
• 4-Iodo-N,N-dimethylbenzamide
• 5-AMINO-ISOPHTHALAMIDE
• IOPROMIDE RELATED COMPOUND A (50 MG) (5- AMINO-N,N'-BIS(2,3-DIHYDROXYPROPYL)-2,4,6-TRIIO- DO-N-METHYL-1,3-BENZENEDICARBOXAMIDE)
• IOPROMIDE RELATED COMPOUND A (50 MG) (5-AMINO-N,N'-BIS(2,3-DIHYDROXYPROPYL)-2,4,6-TRIIO-DO-N-METHYL-1,3-BENZENEDICARBOXAMIDE)
• 2,4-DIIODO-3,5-DIMETHYLANILINE