4-Hydroxybenzophenone
4-Hydroxybenzophenone Basic information
- Product Name:
- 4-Hydroxybenzophenone
- Synonyms:
-
- (4-hydroxyphenyl)phenyl-methanon
- 4-hydroxy-benzophenon
- 4-Hydroxydiphenylketone
- 4-Hydroxyphenylphenylketone
- Benzophenone, 4-hydroxy-
- benzoylphenol
- P-BENZOYLPHENOL
- POB
- CAS:
- 1137-42-4
- MF:
- C13H10O2
- MW:
- 198.22
- EINECS:
- 214-507-1
- Product Categories:
-
- Aromatics, Metabolites & Impurities
- Organic Photoinitiators
- FINE Chemical & INTERMEDIATES
- Aromatic Benzophenones & Derivatives (substituted)
- Benzophenone
- Polymerization Initiators
- Aromatics
- Metabolites & Impurities
- bc0001
- 1137-42-4
- Mol File:
- 1137-42-4.mol
4-Hydroxybenzophenone Chemical Properties
- Melting point:
- 132-135 °C(lit.)
- Boiling point:
- 260-262°C 42mm
- Density
- 1.1184 (rough estimate)
- vapor pressure
- 0Pa at 20℃
- refractive index
- 1.5954 (estimate)
- Flash point:
- 260-262°C/24mm
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Powder
- pka
- 8.14±0.13(Predicted)
- color
- White to beige to brown
- Water Solubility
- Insoluble in water.
- BRN
- 777776
- LogP
- 1.6 at 35℃
- CAS DataBase Reference
- 1137-42-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4)
- EPA Substance Registry System
- Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37-24/25-36
- WGK Germany
- 2
- RTECS
- PC4959775
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29145000
MSDS
- Language:English Provider:4-Hydroxybenzophenone
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
4-Hydroxybenzophenone Usage And Synthesis
Chemical Properties
white to beige fine crystalline powder
Uses
4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.
Uses
Metabolite of benzophenone.
Definition
ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.
Preparation
Preparation by condensation of benzotrichloride,
? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074
The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016
Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0
Flammability and Explosibility
Not classified
Purification Methods
Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]
4-Hydroxybenzophenone Preparation Products And Raw materials
Preparation Products
Raw materials
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4-Hydroxybenzophenone(1137-42-4)Related Product Information
- Acetaldehyde
- HYDROXYAPATITE TYPE I
- Diphenyl ether
- Phenyl salicylate
- Glycolic acid
- Benzophenone hydrazone
- Benzophenone
- PHENYL VALERATE
- Hydroxy silicone oil
- 4-Chlorobenzophenone
- 4-Methoxybenzophenone
- AKOS BB-9928
- PHENYL RESIN
- 2,3,3',4'-TETRAMETHOXYBENZOPHENONE
- 3,4-Dihydroxybenzophenone
- 2,4-Dihydroxybenzophenone
- 2,6-DIHYDROXYANTHRAQUINONE
- 2,2'-Dihydroxy-4-methoxybenzophenone