4-Hydroxybenzophenone Chemical Properties

Melting point:

132-135 °C(lit.)

Boiling point:

260-262°C 42mm

Density 

1.1184 (rough estimate)

vapor pressure 

0Pa at 20℃

refractive index 

1.5954 (estimate)

Flash point:

260-262°C/24mm

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Powder

pka

8.14±0.13(Predicted)

color 

White to beige to brown

Water Solubility 

Insoluble in water.

BRN 

777776

InChI

1S/C13H10O2/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h1-9,14H

InChIKey

NPFYZDNDJHZQKY-UHFFFAOYSA-N

SMILES

Oc1ccc(cc1)C(=O)c2ccccc2

LogP

1.6 at 35℃

CAS DataBase Reference

1137-42-4(CAS DataBase Reference)

NIST Chemistry Reference

Methanone, (4-hydroxyphenyl)phenyl-(1137-42-4)

EPA Substance Registry System

Methanone, (4-hydroxyphenyl)phenyl- (1137-42-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37-24/25-36

WGK Germany 

2

RTECS 

PC4959775

Hazard Note 

Irritant

TSCA 

TSCA listed

HS Code 

29145000

Storage Class

11 - Combustible Solids

Hazard Classifications

Aquatic Chronic 3
STOT RE 2

MSDS

• Language:English Provider:4-Hydroxybenzophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Hydroxybenzophenone Usage And Synthesis

Chemical Properties

white to beige fine crystalline powder

Uses

4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate.

Uses

Metabolite of benzophenone.

Preparation

Preparation by condensation of benzotrichloride,
with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath;
with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group.

Definition

ChEBI: 4-Hydroxybenzophenone is a member of benzophenones.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074
The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016
Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0

Flammability and Explosibility

Not classified

Purification Methods

Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.]

4-Hydroxybenzophenone(1137-42-4)Related Product Information

• Acetaldehyde
• HYDROXYAPATITE TYPE I
• Diphenyl ether
• Phenyl salicylate
• Glycolic acid
• Benzophenone hydrazone
• Benzophenone
• PHENYL VALERATE
• Hydroxy silicone oil
• 4-Chlorobenzophenone
• 4-Methoxybenzophenone
• AKOS BB-9928
• PHENYL RESIN
• 2,3,3',4'-TETRAMETHOXYBENZOPHENONE
• 3,4-Dihydroxybenzophenone
• 2,4-Dihydroxybenzophenone
• 2,6-DIHYDROXYANTHRAQUINONE
• 2,2'-Dihydroxy-4-methoxybenzophenone