(+)-Polyneuridine Chemical Properties

Melting point:

243-246℃

Boiling point:

513.0±50.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

pka

14.79±0.10(Predicted)

(+)-Polyneuridine Usage And Synthesis

Uses

Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties[1][2].

IC 50

κ Opioid Receptor/KOR

References

[1] Yuanyuan Hou, et al. Microfractionation Bioactivity-Based Ultra Performance Liquid Chromatography/Quadrupole Time-Of-Flight Mass Spectrometry for the Identification of Nuclear factor-κB Inhibitors and β2 Adrenergic Receptor Agonists in an Alkaloidal Extract of the Folk Herb Alstonia Scholaris. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:98-104. DOI:10.1016/j.jchromb.2012.10.004
[2] J R Menzies, et al. Opioid Activity of Alkaloids Extracted From Picralima Nitida (Fam. Apocynaceae). Eur J Pharmacol. 1998 May 29;350(1):101-8. DOI:10.1016/s0014-2999(98)00232-5

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