TRANSFORMING GROWTH FACTOR-BETA1, HUMAN Chemical Properties

storage temp. 

−20°C

form 

powder

biological source

rabbit

Safety Information

Hazard Codes 

B

WGK Germany 

3

HS Code 

3504009000

MSDS

• Language:English Provider:SigmaAldrich

TRANSFORMING GROWTH FACTOR-BETA1, HUMAN Usage And Synthesis

Uses

Anti-Activin receptor type IA (ACVR1) (CENTER R147) antibody produced in rabbit has been used in immunohistochemistry (1:100) and western blot (1:100).

Biological Activity

Activin A receptor type 1 (ACVR1) protein can bind activin in concert with activin receptor type 2 (ActRII) or activin receptor type-2B (ActRIIB). It participates in activin signaling. It is also capable of forming a complex with either the bone morphogenetic protein (BMP)-2/7-bound bone morphogenetic protein receptor type II (BMPR-II) or activin A receptor type 2A/2B (ACVR2A/ACVR2B). Somatic mutations of the ACVR1 gene are associated with primary ovary and colon cancer. It is considered a target gene to fibrodysplasia ossificans progressiva (FOP).

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