ChemicalBook > Product Catalog > Biochemical Engineering > nucleic acid drugs > N-(2-Hydroxyethyl)adenosine
N-(2-Hydroxyethyl)adenosine
N-(2-Hydroxyethyl)adenosine Basic information
- Product Name:
- N-(2-Hydroxyethyl)adenosine
- Synonyms:
-
- NSC 54251
- (2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-di
- N-(2-Hydroxyethyl)adenosine
- 6-Hydroxyethyladenosine
- N6-(2-Hydroxyethyl)adenosine
- (2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)aMino)-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
- (2R,3R,4S,5R)-2-(6-((2-Hydroxyethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4
- Adenosine, N-(2-hydroxyethyl)-
- CAS:
- 4338-48-1
- MF:
- C12H17N5O5
- MW:
- 311.29
- EINECS:
- 200-001-2
- Mol File:
- 4338-48-1.mol
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N-(2-Hydroxyethyl)adenosine Chemical Properties
- Melting point:
- 194-195℃
- Boiling point:
- 725.8±70.0 °C(Predicted)
- Density
- 1.88
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.11±0.70(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C12H17N5O5/c18-2-1-13-10-7-11(15-4-14-10)17(5-16-7)12-9(21)8(20)6(3-19)22-12/h4-6,8-9,12,18-21H,1-3H2,(H,13,14,15)/t6-,8-,9-,12-/m1/s1
- InChIKey
- BBOCDRLDMQHWJP-WOUKDFQISA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NCCO)N=C2)[C@H](O)[C@@H]1O
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N-(2-Hydroxyethyl)adenosine Usage And Synthesis
Uses
N-(2-Hydroxyethyl)adenosine has been studied as an anticonvulsant through the activation of adenosine A1 receptor (AA1R).
in vivo
N6-(2-Hydroxyethyl)adenosine (20-40 mg/kg, ip, once daily for 6 weeks) reduces the blood glucose level and diabetes-induced kidney damage, increases the activities of antioxidant enzymes (such as SOD, catalase CAT and GSH) in renal tissue, reduces the level of malondialdehyde (MDA), exhibits anti-inflammatory and antioxidant activities, and ameliorates Alloxan (HY-W017227)-induced diabetes in rats models[2].
N6-(2-Hydroxyethyl)adenosine (75-150 mg/kg, po, once daily for 19 days) exhibits antitumor effect in SGC-7901 xenograft mouse models[4].
| Animal Model: | Alloxan-induced diabetes in rats models[2] |
| Dosage: | 20-40 mg/kg |
| Administration: | ip, once daily for 6 weeks |
| Result: | Reduced the levels of blood glucose, serum creatinine (Scr), blood urea nitrogen (BUN) and urine protein. Reduced the levels of TNF-α, IL-1β, IL-6, TGF-β1 and NF-κB in kidney tissue. Alleviated the damage of glomeruli and renal tubules. |
| Animal Model: | SGC-7901 xenograft mouse models[4] |
| Dosage: | 75-150 mg/kg |
| Administration: | po, once daily for 19 days |
| Result: | Reduced tumor volume and weight. |
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